4th Year Pharmacology Flashcards
action of methotrexate?
interferes with folate metabolism
how is methotrexate given?
injection once a week or tablet once a week
co-prescribed with folic acid taken once a week on a different day
action of leflunomide
interferes with production of pyrimidine
side effects of leflunomide
peripheral neuropathy
teratogenic
action of hydroxychloroquine
interferes with toll-like receptors
examples of anti-TNF drugs
adalimumab infliximab golimumab certolizumab etanercept
action of etanercept?
protein that binds to TNF to the Fc portion of IgG to reduce its activity
acute management of gout
NSAIDS first line
colchicine (if GI, renal, bleeding or asthmatic)
adverse of colchicine
diarrhoea
what are drugs that end in -nib?
JAK inhibitors
side effects of methotrexate
teratogenic
pulmonary fibrosis
side effects of leflunomide
hypertension
peripheral neuropathy
side effects of sulfasalazine
male infertility
side effects of hydroxychloroquine
nightmares
reduced visual acuity
side effects of anti-TNK
reactivation of TB or hep B
