3.7 Cancer Genetics

Question 1

Define Benign

Answer 1

remains localized

Question 2

Define Malignant

Answer 2

invades other tissues

Question 3

Define Metastasis

Answer 3

tumor cells induce secondary tumors

Question 4

Define Oncogenes

Answer 4

mutated, dominant-acting stimulatory genes that cause cancer.

Question 5

Define Tumor suppressor genes

Answer 5

Mutated recessive acting inhibitor genes that are inactive

Question 6

What is the singular key event in cancer progression

Answer 6

Genomic instability

Question 7

Explain dif roles of tumor suppressor genes and oncogenes in cancer initiation and progression

Answer 7

Proto oncogenes normally produce factors that stimulate cell division while tumor suppressor genes inhibit cell division. Oncogenes need a single hit to be activated but tumor suppressors need a double hit to be inactivated.