30. Reteta: Varice necomplicate membre inferioare

Question 1

Rp1

Answer 1

Rp/Lioton gel tub 1000 UI/g
AO nr I (unu)
DS local 3x1 aplicatie/zi, 14 zile

Question 2

1.Clasificare

Answer 2

Lioton gel (heparina sodica)-antitrombotic, anticoagulant, inhibitori ai trombinei, heparina standard nefractionata

Question 3

2.Forma farmac + doza+cai:

Answer 3

Lioton gel flac 100g, 1000U.I/g local, cutanat
Heparina: 5000UI, fiole 1mL, f 5mL, s.c. , i.v.

Question 4

4. Actiune FD

Answer 4

-act anticoagulanta asupra fact plasm ai coag: IIa, IXa,Xa,XIa,XIIa
-inhibitia trombinei
-act. antiplachetara, lipolitica
- creste permeabilitate vasculara

Supraveghem obligatoriu:
 timpul de coagulare = 2-3xVN (VN=8-12min)
 Prima determ: dupa adm celei de-a 2a doze!

Heparina = NU traverseaza placenta -> poate fi utilizata la GRAVIDE

NU se intrerupe brusc tratam, creste risc de hipercoagulabilitate cu aparitia de tromboze si embolii

Question 5

5.Indicatii terapeutice

Answer 5

Lioton gel:
 TVP si embolie pulmonara
 profilaxia trombozei murale si a IMA
 coagulare intravasculara diseminata
 heparinizarea sangelui
 in mentinerea recanalizarii arterelor coronare dupa medicatie trombolitica

Question 6

6.Efecte adverse

Answer 6

Lioton gel:
 hemoragia -> antidot: Sulfat de protamina
 trombocitopenie ± tromboza, R alergice
 osteoporoza (>15 000 UI/zi, >6luni), necroze tisulare
 Rar: alopecie reversibila,

Question 7

7.Contraindicatii

Answer 7

Lioton gel:
 hemofilie, trombocitopenie
 TBC
 ulcer GD, HTA severa
 adm im => Hematoame!!
 fragilitate capilara, endocardita
 IH sau IR, nastere
 Post interventie chirurgicala