28.Reteta: Anemie megaloblastica pt 1 luna tratament, 60 ani Flashcards

1
Q

Rp1/2

A

Rp1/Ciancobalamina f 50 µg
F nr XXXII (treizeci si doi)
DS im 2x1 fiola/zi, 14 zile, apoi 2x1 fiola/saptamana, 2 saptamani
#
Rp2/Acid folic dj 5 mg
AO nr I (unu)
DS oral 3x1 dj/zi, 1 luna

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2
Q

1.Clasificare

A

Ciancobalamina – antianemic (Vitamina B12)
Acid folic – antianemic, vitamina B9

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3
Q
  1. F farmaceutica + doza+cale
A

Ciancobalamina fiole 50 µg/mL, 1000µg/mL, i.m. , s.c.

Acid folic dj 5 mg (oral); gravida: 1dj/zi in lunile ce preced conceptia; adulti: 3x1 dj/zi, oral

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4
Q

3.Actiune FD

A

Ciancobalamina:
-Esențială pentru maturarea eritrocitelor
- sprijina diviziunea celulara eficienta
-alimenteaza celulele progenitoare ale eritrocitelor cu cant necesara de vitamina B12

Acid folic:
-ajuta la maturarea eritrocitelor în măduva osoasă
-acționează sinergic cu vit B12

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5
Q

4.Indicatii terapeutice

A

Ciancobalamina:
 anemie megaloblastiaca; prin carenta de B12
 tulburari neurologice, neuropatii
 hepatite cronice si ciroza

Acid folic:
 anemia megaloblastica prin deficit de acid folic
 profilactic in sarcinaimpiedica aparitia spinei bifide la fat
 profilaxia si tratamentul toxicitatii Metotrexatului
 anemii hemolitice cronice severe

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6
Q
  1. Efecte adverse
A

Ciancobalamina:
rar alergie, e bine tolerata, in doze mari urina e rosie

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7
Q
  1. Contraindicatii
A

Ciancobalamina: in tumori maligne;
acid folic: impreuna cu chimioterapice antimicrobiene

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