3: Immunology - Henoch - Schonlein Purpurs Flashcards
What is henoch-schoenlein purpura
immune-mediated small-vessel vasculitis
What condition does henoch-schoenlein purpura overlap with
Berger’s disease (IgA nephropathy)
When does henoch-schoenlein purpura present
Before age 10 (90%)
What is the peak age of henoch-schoenlein purple
6-years
In which gender is henoch-schonlein purpura more common
Boys
What precedes henoch-schonlein purpura
URTI
Vaccinations
Medications
What organism usually causes URTI predisposing henoch-schonlein purpura
Group A streptococcus
What vaccinations may precede henoch-schonlein purpura
Yellow-Fever
Cholera
How will henoch schonlein purpura present clinically
URTI 1-3W later:
- Athritis
- Palpable purpuric rash over buttocks
- Colicky abdominal pain
Where does palpable purpuric rash present
Buttocks
How may children with henoch schonlein purpura present
Limp - due to arthritis of knees and ankles
What are 3 other symptoms of henoch schonlein purpura
- Melena
- Scrotal swelling
.3 Nephritic syndrome
Explain pathophysiology of henoch schonlein purpura
Allergens cause activation IgA, which deposits in vascular walls and causes activation of complement
What investigations are ordered in henoch-schonlein purpura
FBC
RFT
U+E
Urinalysis
What will be seen on FBC in henoch-schonlein purpura
Thrombocytosis
