2: Endocrine - Hypothyroidism Flashcards

1
Q

What are the two types of paediatric hypothyroidism

A
  • Congenital

- Acquired

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2
Q

Which gender is congenital hypothyroidism more prevalent

A

Female

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3
Q

What are 5 causes of congenital hypothyroidism

A
  • Thyroid gland dysgenesis (85%)
  • Pendred syndrome
  • Iodine deficiency
  • Congenital TSH absence (Rare)
  • Maternal medications - propylthiouracil
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4
Q

What is Pendred syndrome

A

Thyroid gland w/ absence thyroid H

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5
Q

What drug can cause congenital hypothyroidism

A

Propylthiouracil

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6
Q

What are causes of acquired primary hypothyroidism

A
  • Hashimotos thyroiditis (85%)
  • Iodine deficiency
  • Reidel thyroiditis
  • De Quervain’s thyroiditis
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7
Q

What are causes of secondary hypothyroidism

A
  • Cranial tumour

- Pituitary irradiation

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8
Q

What is riedel’s thyroiditis

A

Infiltration thyroid gland with fibrous tissue

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9
Q

What is Dequervain’s thyroiditis

A

Post-infection there is inflammation thyroid gland causes hyperthyroidism followed by hypothyroidism

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10
Q

What are 5 symptoms of congenital hypothyroidism

A
  1. Prolonged jaundice
  2. Puffy face
  3. Macroglossia
  4. Short-stature
  5. Hypotonia
  6. Developmental Delay
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11
Q

Explain puberty in acquired hypothyroidism

A

Delayed puberty. Can present with pseudo-puberty where there is isolated breast or testes development

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12
Q

What can congenital hypothyroidism lead to

A

Cognitive impairment

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13
Q

What is used to investigate congenital hypothyroidism

A

Neonatal heel prick test at 5-9d, looks for TSH

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14
Q

If neonatal heel prick is positive, what is next-line investigation

A

Thyroid US to identify dysgenesis = most common cause

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15
Q

How is acquired hypothyroidism diagnosed

A

TFTs, then autoantibody test

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16
Q

If patients have autoimmune hypothyroidism, what antibodies are usually present

A

anti-TPO and anti-thyroglobulin

17
Q

How is congenital hypothyroidism managed

A

Levothyroxine