2: Paediatric MSK - JIA, Rickets, DDH, Leg-Calve Perthes, Slipped Upper Epiphyseal Plate, Transient Synovitis, Osgood Schlatter's Flashcards
What is juvenile idiopathic arthritis
Onset of rheumatic joint disease before age of 16. Involving joint inflammation for more than 6 weeks
Why is a timeframe of 6W set on JIA
To differentiate from septic arthritis
What age-group does JIA occur in
<16Y
What gender is JIA more common in
Females
What is the most common for of JIA
Oligo-articular JIA
What is oligoarticular JIA
JIA affecting less than 4 joints within 6 months
What joints are affected first in oligoarticular JIA
large weight-bearing joints
What is associated with oligoarticular JIA
anterior uveitis
How will oligoarticular JIA present on blood tests
- Raised ESR/CRP
- -ve RF
- positive ANA
How will seronegative polyarticular JIA present
affects more than 5 joints within 6 months of onset
How will polyarticular JIA present on blood tests
- Raised ESR/CRP
- -ve RF
- positive ANA
What blood test is positive in seropositive polyarticular JIA
Positive RF
What is systemic JIA called
Still’s disease
In which age group is Still’s disease more common
2-4y
What is the clinical criteria for stills disease
Must have
- More than one joint involved
- Intermittent fever for at least 2W, with T spikes on at least 3d
- One extra-articular manifestation
What are extra-articular manifestations of stills disease
- Salmon pink rash
- Lymphadneopathy
- Hepatosplenomegaly
- Serositis
How will arthritis present in still’s disease
Red swollen joint
Early morning stiffness
Limited/painful movement
Who manages JIA
Paediatric rheumatology
Describe management of JIA
- Physio
- Encourage swimming/cycling
- Orthoses
- Naproxen
- Intra-articular corticosteroid injections
What is the prognosis of JIA
95% resolves by puberty
What are 4 complications of JIA
- Serositis (pericarditis, pleuritis)
- Growth retardation secondary to premature epiphyseal plate closure
- Chronic anterior uveitis
- Leg-length discrepancy
In a child 0-5y what are the causes of a limp affecting the back
Discitis
In a child 0-5y what are the 3 causes of a limp affecting the hip
- Transient synovitis
- Developmental dysplasia
- Septic arthritis
In a child 0-5y what is a causesof a limp affecting the femur
- Osteomyelitis
In a child 0-5y what is a cause of a limp affecting the knee
- Septic arthritis
In a child 5-10y what are the 3 causes of a limp affecting the hip
- Transient synovitis
- Perthe’s disease
- Septic arthritis
In a child 5-10y what are the 2 causes of a limp affecting the knee
- Discoid meniscus
- Septic arthritis
In a child 10-15y what are the 2 hip
- Septic arthritis
- Slipped upper epiphyseal disc
In a child 10-15y what are the 3 conditions causing limp at the knee
- Osgood schlatters
- PFP syndrome
- Osteochondritis dessicans
What is the commonest cause of a child with a limp
Trauma
What age is septic arthritis more common
<2
How will septic arthritis present
- Affects single synovial joints
- Erythematous, warm, swollen joint
- Child may present with a limp
What is osteomyelitis
- Infection of metaphysic of long bone
How will child present with osteomyelitis infection
- febrile, painful and immobile limb. Overlying skin may be swollen, hot and erythematous.
What is the commonest cause of paediatric hip pain
transient synovitis
What age group does transient synovitis occur
2-12
How will transient synovitis present
- Afebrile
- Acute hip pain on movement, that is ok on rest
What condition is juvenile idiopathic arthritis associated with
Chronic anterior uveitis
What should be done to prevent blindness in JIA
Regular eye screening
Why may children with JIA have growth retardation
Chronic inflammation can cause stiffening and deformity of the joints.
Also chronic disease - present with frequent infections, malnutrition, stress and corticosteroid use.
Define rickets
Poor bone mineralisation prior to fusion or epiphyseal plates
What is poor bone mineralisation after epiphyseal fusion called
Osteomalacia
What cause rickets
Deficiency in vitamin D:
- Malnutrition - low vitamin D diet
- Poor sunlight exposure
- Malabsorption
- Impaired hydroxylation: liver or kidney disease
- Congenital defect in metabolism
Does breast milk have a high or low vitamin D concentration
Low
What can cause malabsorption of vitamin D
Coeliac Disease
What is the clinical presentation of Ricket’s disease
- Bending of long bones
- Knocked Knees
- Bow legs
- Harrison groove
- Rachitic rosary
- Marfan’s sign
What is rachitic rosary
Distention of bone-cartilage junction at ribs
What is marfans sign
Increase space between bone-cartilage junctions
What is Harrison groove
Softened lower rib are pulled in by the diaphragm causing a groove at thoracic outlet.
Explain normal vitamin D processing
- Cholecalciferol (D3) is ingested or made in the skin by converting UVB
- Liver hydoxylates D3 to 1-OH vitamin D
- Kidney hydroxylates D3 to 1,25 di-OH vitamin D3
- Vitamin D deficiency results in decrease mineralisation and hypocalcaemia. Causing PTH release
What is first-line investigation of vitamin D deficiency
Bone profile