2: GI - Duodenal Atresia, Coeliac Disease, Hernias, Functional Abdominal Pain, Hirschsprung's, IBD Flashcards
What is duodenal atresia
Complete occlusion of the duodenum
What is duodenal stenosis
Narrowing of duodenum
What condition is duodenal atresia associated with
Down’s Syndrome (30%)
How will an infant with duodenal atresia present in-utero
Polyhydramnios
Why does a foetus with duodenal atresia have polyhydramnios
Unable to swallow and process amniotic fluid
What are neonatal features of duodenal atresia
- Billous post-partum vomiting
- Meconium ileum
- Distended upper abdomen
- Scaphoid lower abdomen
Why is vomiting bilious in duodenal atresia
Obstruction after major duodenal papilla
Why is scaphoid lower abdomen in duodenal atresia
No gas in abdomen beyond the obstruction
What is used to investigate duodenal atresia
AXR
What is seen on AXR
Double-bubble sign
What is the double-bubble sign
Accumulation of gas before the stenosis and after the stenosis - giving appearance of two bubbles
How is duodenal atresia managed
- Gastric decompression
- Parental nutrition
- Duodenostomy
What is coeliac disease
Enteropathy caused by sensitivity to gluten
When does coeliac disease typically present in children
4-6 months
- Introduction of solid foods
What gene is most associated with coeliac disease
HLADQ2 (95%)
Aside from HLA DQ2, what other gene is associated with coeliac disease
HLADQ8 (10%)
What happens in coeliac disease
Gliadin triggers an auto-immune reaction
How does coeliac disease present clinically
- Diarrhoea
- FTT
- Distended abdomen
- Everted umbilicus
- Irritability
- ANAEMIA
What is a late presentation of coeliac disease
Wasting of the buttocks
What are very late signs of coeliac disease
- Hypotonia
- Apathy
- Delayed puberty
- Gross motor developmental delay
How is coeliac disease stereotypically identified on growth chart
4-6m (gluten introduced) will be crossing-down of centiles
What is first-line investigation for coeliac disease
anti-TTG (IgA)
What is second-line investigation for coeliac disease
anti-EMA
What is third-line for coeliac disease
Total IgA
When is serology for coeliac disease less reliable
Under 18 months
What imaging should be ordered in coeliac disease
Endoscopy (OGD)
Explain management of coeliac disease
Gluten-free diet
What is a complication of coeliac disease
Increases risk of small bowel lymphoma, even if asymptomatic
What are the three types of hernias that may occur in children
Umbilical
CDH
Inguinal
What is an umbilical hernia
Protrusion abdominal contents through umbilicus
What can cause umbilical hernia
Increase intra-abdominal pressure
Describe clinical features of umbilical hernia
- Mass protruding through umbilicus
- Increased on increasing intra-abdominal pressure
- Can be easily reduced
What are two differential diagnoses of umbilical hernia
- Omphalocele
- Gastrochisis
What is an omphalocele
Organs herniate through midline abdominal wall
When do majority of umbilical hernias resolve by
2-3 years
What are the TWO indications for repair of umbilical hernia
- > 4-years
2. > 1.5cm
What is gastrochisis
Paraumbilical herniation intestine
Will inguinal hernias in paediatrics be direct or indirect and why
Indirect - due to patent processes vaginalis
Will indirect inguinal hernias be medial or lateral to the inferior epigastric vessels
Lateral to inferior epigastric vessels
Describe position of inguinal hernias relative to pubic tubercle
Superior-medial
When are inguinal hernias most common in paediatrics
Before 1-year
What causes inguinal hernias
Patent processes vaginalis
What are 4 risk factors for inguinal hernias
- FH
- Male
- Pre-Mature
- Raised intra-abdominal pressure
What can cause raised intra-abdominal pressure
Prolonged ventilation
What is the main presentation of inguinal hernia in children
Intermittent swelling inguinal-scrotal region
What is the main risk with inguinal hernias
Strangulation
What is strangulation
Occlusion blood supply resulting in necrosis
How will strangulation of an inguinal hernia
- Irritability
- Absolute bowel obstruction (no defectation or flatulence)
What are two factors that increase risk strangulation inguinal hernia
- Smaller hernia
- Younger child
What is the main differential diagnosis of inguinalscrotal swelling, aside from inguinal hernia
Hydrocele