1: Immunology, Allergy - Anaphylaxis Flashcards
Define anaphylaxis
Life-threatening allergic event due to immediate hypersensitivity reaction
What is the most common cause of anaphylaxis in children
Food substances
What food-types can cause anaphylaxis
- Peanuts
- Eggs
- Shellfish
What are other triggers for anaphylaxis
Medication (Penicillin)
Stings, Bites
Injections - radiocontrast dye
Describe clinical presentation of anaphylaxis
Skin: Urticaria, Angioedema
Resp: Airway obstruction - bronchospasm, laryngeal oedema
GI: diarrhoea, abdo cramps
Systemic shock
Explain pathophysiology of anaphylaxis
IgE cross-link mast cells to cause release of histamine. Which causes smooth muscle contraction and peripheral vasodilation - leading to bronchospasm, abdominal cramps.
Describe approach to anaphylaxis patient
- Contact resus team
- A-E approach
- Lie patient on their back with their legs raised
What 3 medications are given in anaphylaxis
- IM adrenaline
- IV chlorphenamine
- IV hydrocortisone
If adrenaline is ineffective, when can second-dose be given
5-minutes later
Aside from chlorphenamine, hydrocortisone and adrenaline - what other interventions are given for anaphylaxis
Remove stimulus
Oxygen
IV Fluids
When is salbutamol indicated for anaphylaxis
If individual is having bronchospasm
Outline management of anaphylaxis
- Contact resus team
- Oxygen
- IM adrenaline
- IV Fluid
- IV hydrocortisone
- IV chlorphenamine
What blood should be taken following anaphylaxis
Mast cell tryptase
When is mast cell tryptase taken
1-2h later
How long should patients be observed for following anaphylaxis and why
Observe patients for 6-hours: due to risk of biphasic attack
What should all individuals be trained how to do before discharge
Use epipen
What is in an epipen
0.3mg Adrenaline (1:1000)
What does of adrenaline is given 6m -6 years
0.15mL (150mcg)
How many grams of adrenaline are in 0.15mL
150mcg
What dose of adrenaline is given 6-12 years
0.3mL (300mcg)
What dose of adrenaline is given above 12 years
0.5 mL (500mcg)
What dose of hydrocortisone is used if under 6-months
25mcg
What dose of hydrocortisone is used if 6-months to 6-years
50mcg
What dose of hydrocortisone is used if 6 years to 12 years
100mcg
What dose of hydrocortisone is used if more than 12 years
200mcg
What dose chlorphenamine is given 6m-6 years
2.5mg
What dose chlorphenamine is given 6-years to 12-years
5mg
What dose chlorphenamine is given after 12-years
10mg
What is allergy
type I, IgE mediated reaction
What is true food allergy
IgE mediated hypersensitivity reaction to food
What can cause allergies
- Food
- Medication
- Dust mite
- Pollen
- Fur