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OBSTETRICS > 2P - Recurrent Pregnancy Loss > Flashcards

2P - Recurrent Pregnancy Loss Flashcards

1
Q

What is the definition of early pregnancy loss?

A

Loss of clinical pregnancy before 20 weeks of AOG

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2
Q

increase in maternal age is directly or indirectly proportional to pregnancy loss?

A

Directly

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3
Q

Incidence rate of early pregnancy loss among aged <35 yrs old and >40 yrs old?

A

9-12% - <35

>50% - >40

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4
Q

Earliest time to ask for ultrasound after last menses to check for gestational sac?

A

5 weeks

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5
Q

Recurrent pregnancy loss based on ASRM?

A

2 or more clinical pregnancy loss not necessarily consecutive

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6
Q

Recurrent pregnancy loss based on ESRH and RCOG?

A

3 consecutive pregnancy losses including non visualized one

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7
Q

What type of RPL refers to multiple pregnancy losses between normal pregnancies?

A

Tertiary RPL

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8
Q

What type of RPL refers to multiple losses in a woman who
has already had a pregnancy beyond 20 gestational
weeks

A

Secondary RPL

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9
Q

What type of pregnancy refers to multiple losses in a woman with no
previous viable infants

A

Primary RPL

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10
Q

50-60% of early pregnancy losses are caused by?

A

Chromosomal abnormalities

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11
Q

Pregnancies with unbalanced translocations usually end up with?

A

Miscarriage

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12
Q

Most common type of chromosomal abnormalities?

A

Aneuploidy

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13
Q

Most common cause of early pregnancy loss <10 weeks?

A

Aneuploidy

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14
Q

Increase in RPL is caused by chromosomal abnormalities T or F?

A

False. Repeated RPL is caused by other factors than chromosomal abnormalities

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15
Q

estimated success rate of live birth after 1 miscarriage?

A

85%

75% after 2 miscarriages

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16
Q

Uterus is formed after separation of mullerian ducts? T or F?

A

False. Should be after joining of mullerian ducts

17
Q

This condition is characterized by having completely non existent uterus?

A

Mayer Rokitansky Kuster Hauser Syndrome

18
Q

Best diagnostic for uterine anomalies?

A

3D ultrasound

19
Q

Most common type of uterine anomaly?

A

Septate uterus - Class V

20
Q

type of uterine myoma causing RPL?

A

Submucous myoma

21
Q

Another name for intrauterine adhesions?

A

Asherman Syndrome

22
Q

intrauterine adhesions usually occur after what conditions?

A

curettage, uterine surgery, infection or complicated birth

23
Q

What is the gold standard diagnosis of chronic endometritis?

A

Immunohistochemistry stains for syndecan 1

24
Q

Treatment for endometritis caused by infection?

A

doxycycline

25
Q

Appearance of uterine cavity in chronic endometritis?

A

Strawberry

26
Q

This autoimmune disorder is characterized by recurrent thrombosis and obstetric morbidity?

A

Antiphospholipid syndrome

27
Q

Obstetric complications associated with APAS?

A

IUGR, prematurity and preeclampsia

28
Q

Diagnostic test for APAS?

A

anti cardiolipin, lupus anticoagulant and anti B2 glycoprotein 1

29
Q

50% of patients with APAS have SLE? T or F?

A

False. 50% of those with SLE have APAS

30
Q

What blood coagulation laboratory test is increased in SLE?

A

aPTT

31
Q

Current treatment standard of APAS?

A

Heparin and low dose aspirin

32
Q

What is the TSH threshold in diagnosing subclinical hypothyroidism in pregnancy?

A

> 2.5 mIU/L

33
Q

What are the metabolic manifestations of PCOS?

A

insulin resistance and hyperinsulinemia,
hyperandrogenaemia, or increased plasminogen
activator inhibitor-1 activity.

34
Q

Treatment for the insulin effects of PCOS?

A

Metformin

35
Q

treatment for luteal phase deficiency?

A

Progesterone supplementation

36
Q

Amount of caffeine per day allowed during pregnancy to prevent RPL?

A

300 mg

37
Q

What is the estimated chance of live birth among women aged <30 years after 2 years of early pregnancy loss?

A

75%

40% for women aged >40 yrs

38
Q

For women with 3 miscarriages, what is the chance of a future live birth within 2 years?

A

70%

45% - 6 miscarriages

OBSTETRICS (36 decks)

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