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Fisiología general > 2.5. Dolor > Flashcards

2.5. Dolor Flashcards

1
Q

r

Nocicepción

A

Proceso fisiológico neural de codificación de un estímulo nocivo (detección y respuesta).

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2
Q

Dolor

A

Experiencia:
Sensorial → real
Desagradable → potencial
Emocional → descrito

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3
Q

Tractos que conducen el dolor

A
  • Espinotalámico
  • Espinoparabraquial
  • Espinomesencefálico
  • Espinoreticular
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4
Q

TRPV1

A
  • Calor 43º
  • Capsaisina
  • Ácido
  • Calor intenso
  • Seesibilización tras lesión tisular
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5
Q

TRPM8

A

Frío moderado a extremo
Mentol

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6
Q

TRPA1

A

Estímulos mecánicos y químicos
Irritantes (isotiocinato de alilo)
Frío

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7
Q

Canales ASIC

A
  • Ácidosis
  • Bajo pH por lesión
  • Relevante en condiciones inflamatorias
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8
Q

NaV1.7

A

Generación PA

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9
Q

NaV1.8

A

propagación PA

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10
Q

NaV1.9

A

Mutación → dolor extremo o insensibilidad congénita
Propagación PA

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11
Q

Nociceptores mecánicos

A

Mecano-sensibles
TRPA1

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12
Q

Nociceptores térmicos

A

TRV1 → calor
TRPM 8 → frío

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13
Q

Nociceptores químicos

A

TRPV1
ASIC
TRPA1

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14
Q

Nociceptores polimodales

A

TRP
ASIC

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15
Q

Kv7

A

Mayor percepción del dolor

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16
Q

TREK1 (K2P2.1)

A

Moduladores negativos del dolor
Hiperpolariza la membrana

17
Q

Cav2.2

A

Reducen transmisión del dolor
Regula liberación NT

18
Q

Cav3.2

A

Amplifican dolor

19
Q

P2X3

A

Activado por ATP
Genera dolor

20
Q

Tx dolor nociceptivo

A

Anestésicos
Paracetamol
Opioides
AINES

21
Q

Tx dolor inflamatorio

A

AINES
Esteroides

22
Q

Fibras A delta

A

Dolor rápido, agudo y bien localizado

23
Q

Fibras C

A

Dolor lento, sordo, difuso y persistente

24
Q

Tx dolor neuropático

A

Antideepresivos
Neuromoduladores
Opioides

25
Q

Hiperalgesia

A

Primaria → periférica
Secundaria → central

26
Q

Componentes principales que participan en el procesamiento de la información dolorosa.

A
  • Terminaciones centrales de las neuronas aferentes primarias.(AP)
  • Neuronas de proyección. (NP)
  • Interneuronas locales. (IL)
  • Glía.
  • Axones provenientes de núcleos supraespinales.
27
Q

Matriz del dolor

A
28
Q

Modulación del dolor

A

Fisiología general (51 decks)

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