14.11 (14.5) Palliative issues in the care of patients with head and neck cancers Flashcards

1
Q

Where do head and neck cancers arise from?

List FOUR locations in the head and neck

A

From epithelial lining of the upper aerodigestive tract & affects oral cavity including:

◆ lips
◆ pharynx
◆ larynx
◆ paranasal sinuses
◆ nasal cavity
◆ salivary glands
◆ middle ear

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2
Q

What type of cancer are most head and neck cancers?

List FIVE risk factors for head and neck cancer

A

Majority are squamous cell carcinoma.

Risk factors:
◆ inc age*
◆ male sex*
◆ low socioeconomic status*

◆ tobacco*
◆ high EtOH intake*
◆ chewing tobacco or betal quid/paan (arica nut)

◆ viral infection with HPV, EBV
◆ premalig lesions (leucoplaia, erythoplakia, lichen planus)

Risk factor not listed in 6th:
◆ mucosal irritation by ill fitting dentures or roughened dental edges

Box 14.11.1

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3
Q

What are the four domains of health that contribute to QOL

A

Physical
Emotional
functional
social

PE FS

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4
Q

Head and neck cancers impact two vital functions

A

swallowing and vocalization

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5
Q

List 5 signs or symptoms that may indicate swallowing dysfunction and should trigger an SLP assessment

A

-inability to control food, liquids, saliva in oral cavity

-pocketing of food in cheek*
-excessive chewing*

-drooling*
-nasal regurgitation*

-cough, choking or throat clearing during swallowing*

-abnormal vocal quality after swallowing
(wet or gurgled voice)
-build up or congestion after meal
-complaint of difficulty swallowing
-weight loss

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6
Q

List two investigations for assessing oropharyngeal swallowing

A

modified barium swallow

fibreoptic endoscopic evaluation of swallowing - gold standard

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7
Q

List three ways that adjuvant xrt contributes to swallowing issues in patients with head and neck cancer

A

mucositis
tissue edema
xerostomia
hyperviscous secretions

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8
Q

What are three disorders of vocalization that can occur in a patient with head and neck cancer

A

disordered speech (structural changes in lips, tongue, teeth and hard palate)
disordered resonance
disordered voice

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9
Q

List 6 specific symptom control issues that may arise in someone with head and neck cancer

A

Most pertinent as per 6th:
◆ pain*
◆ oral care & mucositis*
◆ sialorrhoea & secretion mgmt
◆ wound care & major bleeds (“carotid blowout”)*
◆ airway obs & trach mgmt*
◆ nutrition & diff swallow*
◆ psych distress & social isolation*

Prev listed other answers:
auditory function
taste alteration
xerostomia
fistula

hypothyroidism

dermatitis
lymphedema

anemia

mood/anxiety disorders
neurocognitive impairment

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10
Q

list 3 interventions for lymphedema in patients with head and neck cancer

A
  • manual lymphatic drainage
  • compression garments
  • education re postural techniques, identification and prevention of infection, exercises to maintain neck and shoulder mobility
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11
Q

List four contributors to poor nutrition in patients with head and neck cancer

A

Cancer related:
- decreased oral intake due to pain
- difficulty swallowing/dex tongue mobility
- mechanical obs by tumor

Treatment related:
- neurological dysfunction
- radiation induced xerostomia/fibrosis
- dental extractions
- lymphedema

FS
Odynophagia
Dysphagia
Obstruction
Treatment related

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12
Q

List four ways to reduce risk of osteoradionecrosis (ORN) in patients with head and neck cancer

A

ORN - ischemic necrosis of bone in a previously irradiated area with associated soft tissue necrosis

—-

stop smoking*
stop EtOH*

use fluoride before bedtime to reduce dental carries*

minimize trauma and exposure to local irritants*

diseased teeth maintained through endodontic tx
for unrestorable teeth retention of roots is preferable to extraction

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13
Q

What is the primary tx for ORN

A

hyperbaric O2

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14
Q

Loss of which type of taste is most correlated to poor QOL

A

umami taste - due to role in triggering interest in eating and enjoyment

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15
Q

What is the most frequent symptom complaint of people receiving XRT for head and neck cancers

A

xerostomia

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16
Q

Name SIX of the most common presenting symptoms of head and neck cancers.*

A

◆ palpable swelling in the mouth
◆ oral ulceration/painful lesion
◆ white (leukoplakia) or red patch (erythroplakia) in the oral cavity

◆ earache

◆ epistaxis/nasal obs
◆ facial pain/swelling
◆ cranial nerve palsy

◆ sore throat
◆ difficult/painful swallowing
◆ lump in the neck - cervical LN or enlarged thyroid
◆ hoarseness

◆ stridor

17
Q

Name ONE cancer related factors which influence incurability of head & neck cancers.

A

◆ dz involving skull base, prevertebral fascia, or encases carotid artery
◆ presence of distant mets*

18
Q

Name TWO patient related factors which influence incurability of head & neck cancers.

A

◆ poor performance status
◆ multiple comorbidities
◆ declined potentially curative tx

19
Q

Name THREE factors influencing overall effectiveness of “salvage surgery”

A

Salvage surgery - sx intervention conducted after the failure of initial anticancer tx with potential curative aim

Factors

◆ good performance status + limited comorbidities

◆ smaller primary tumors (stage I or II)
◆ dz free period for at least 6 months after initial tx
◆ directed at larynx/oral cavity VS oro-hypopharynx

20
Q

Name THREE indications for palliative sx in the mgmt of head & neck cancers

A

◆ tumor debulking
◆ fistula closure
◆ airway patency (w/ trach)
◆ sclera protection (w/ lat. tarsorrhaphy = sew eyelid shut)

21
Q

How is palliative radiation different vs curative intent radiation in head & neck cancers.

A

Decreased everything:
◆ total dose (~40 Gy vs 60-70 Gy in cure)
◆ number of #s (WP: “# of #s”)
◆ duration of tx

22
Q

Name TWO challenges with decision making and communication w/ head & neck cancer pts.

A

◆ Reduced health literacy vs general pop (WP: ?one study -> Koay et al. 2013)

◆ Comm difficulties - dz/tx impact vocalization*

◆ High prevalence of ethical quandaries:*
- mgmt catastrophic bleed
- hydration & nutrition
- airway mgmt

23
Q

List TWO medications for sialorrhoea

A

◆ saline nebs
◆ antimuscarinic medications
- hyoscine butylbromide
- hyoscine hydrobromide
- glycopyrrolate

24
Q

What is “carotid blowout”?

Name FOUR risk factors.

A

◆ Bleeding from extracranial carotid arteries or major branches which is likely to result in death within a time frame as short as minutes

Risk Factors:
◆ prev rads
◆ ext sx

◆ wound breakdown
◆ local infection

◆ local tumor recurrence
◆ dev of pharyngocutaneous fistula

25
Q

“carotid blowout”:

  • How to diagnose?
  • Definitive treatments (2)
  • Initial treatments (2)
  • Palliative treatments (2)
A

◆ Angiography to provide dx confirmation

——

◆ Definitive tx:
- endovas stenting/embolization
- radiotherapy
- laser ablation

——-

◆ Initial treatments:
- d/c anticoagulants
- consider TXA
- local measures: 1:1000 adrenaline on gauze

——

◆ Discussion/education potential risks of carotid blowout to patient & family

◆ Pall sedation prep: crisis midaz + dark towels

◆ Consider healthcare provider “debrief”

26
Q

Name THREE potential reasons for higher suicide risk in head & neck pts vs general cancer population

A

◆ disfigurement
◆ social isolation, secondary to
- appearance
- inability to engage in social interactions (eg. eating)
◆ pre-existing mental health
◆ prev substance use disorder
◆ fragmented social situation