14-02 ALL EMBRYO II 2018 - Urinary Flashcards
urinary bladder with trigone
[anong embryonic origin nitong adult deriative na ‘to?]
upper wide 3rd of urogenital sinus
loop of Henle
[anong embryonic origin nitong adult deriative na ‘to?]
metanephros (metanephric blastema)
penile phallic urethra
[anong embryonic origin nitong adult deriative na ‘to?]
lower longer 3rd of urogenital sinus
major and minor calyces
[anong embryonic origin nitong adult deriative na ‘to?]
ureteric bud
prostatic & membranous urethrae of male
[anong embryonic origin nitong adult deriative na ‘to?]
mid constricted 3rd of urogenital sinus
minor calyx
[anong ANLAGEN nitong ADULT DERIVATIVE na ‘to?]
ureteric bud
renal pelvis
[anong ANLAGEN nitong ADULT DERIVATIVE na ‘to?]
ureteric bud
major calyx
[anong ANLAGEN nitong ADULT DERIVATIVE na ‘to?]
ureteric bud
loop of Henle
[anong ANLAGEN nitong ADULT DERIVATIVE na ‘to?]
Blastema
Bowman’s Capsule
[anong ANLAGEN nitong ADULT DERIVATIVE na ‘to?]
Blastema
A 2-day patient has a presenting sign of ambiguous external genitalia with enlared abdomen with palpable mass 7x10.5cm at the back extending to the lumbar area, left. patient was subjected to abdominal ultrasound which reveals the following pertinent results: (+) to consider Wilm’s Tumor, left (+) Polycystic Xidney Disease, right. While, the rest of the Complete Physical Examination findings are within normal findings. What’s your initial impression?
Denys-Drash Syndrome
Autosomal Recessive Congenital Polycystic Kidney Disease
most often leads to early & emergency dialysis secondary to renal failure
The following leads to “ascent of the kidneys” EXCEPT:
a. lumbosacral vertebral bodies’ growth & enlargement
b. development of thoracic & sacral spinal curvatures
c. complete fibrous obliteration of allantois to urachus
d. regression of mesonephros
c. complete fibrous obliteration of allantois to urachus
“The definitive adult-type of kidney” anlage:
metanephros
Chromosome 10q24.3-25.1 is:
PAX-2
blocks apoptosis that delays canal between Bellini & forming nephron
[GENE for this regulatory function]
BMP-7
“scatter factor” is recognized by this proto-oncogene receptor
[GENE for this regulatory function]
met
regulates transformation of blastemal caps into renal vesicles
[GENE for this regulatory function]
PAX-2
master gene for “kidney formation” in a very regulated expressions
[GENE for this regulatory function]
WT-1
regulates transformation of renal vesicles into renal tubules
[GENE for this regulatory function]
WNT-4
segmentation of pronephros into 7-10 cell masses
[GENE for this regulatory function]
PAX-1
BLOCK apoptosis & allow proliferation of nephron
[GENE for this regulatory function]
BMP-7 & FGF-2
INDUCE branching of ureteric bud into calyces
[GENE for this regulatory function]
GDNF & Scatter factor
Master gene for blastema becoming “the KIDNEY”
[GENE for this regulatory function]
WT-1
regulates renal vesicles into tubules & Henle
[GENE for this regulatory function]
WNT-4
regulates blastemal cap into renal vesicles
[GENE for this regulatory function]
PAX-2
mutated gene for Melnick-Fraser Syndrome
[GENE for this regulatory function]
EYA-1
mutated gene for Townes-Brocks Syndrome
[GENE for this regulatory function]
SALL-1
HGF’s proto-oncogene receptor
[GENE for this regulatory function]
Met
GDNF’s proto-oncogene receptor
[GENE for this regulatory function]
Ret
ductuli deferentes; epididymis; paradidymis vas deferens; seminal vesicle; ejaculatory ducts
[Anlagen for these derivatives]
Wolffian Duct
Fallopian Tubes; uterus upper 3rd of vagina
[Anlagen for these derivatives]
Müllerian duct
Phallic urethra of penis
[Anlagen for these derivatives]
Lower longer 3rd of urogenital sinus
urinary bladder
[Anlagen for these derivatives]
upper wide 3rd of urogenital sinus
membranous urethra of male
[Anlagen for these derivatives]
mid constricted 3rd of urogenital sinus
Henle’s loop; proximal and distal convoluted tubules; Bowman’s capsules
[Anlagen for these derivatives]
Blastema
Ureters; renal pelvis; major and minor calyces; Malphighii pyramids, collecting tubules of Bertin
[Anlagen for these derivatives]
ureteric bud
Median umbilical ligament
[Anlagen for these derivatives]
urachus of allantois
external urethral meatus of glans penis
[Anlagen for these derivatives]
epithelial solid cord tag
pronephros; rhesonephrosl & metanephros
[Anlagen for these derivatives]
Intermediate mesoderm
master gene for METANEPHROS or BLASTEMA becoming the Adult Definitive Type of KIDNEY SYSTEM
[gene for this molecular regulatory function]
WT-1
Blocks “apoptosis” or any caspase action which allows proliferation of nephron
[gene for this molecular regulatory function]
BMP-7 + FGF-2
Regulates blastemal caps’ transformation into “Renal Vesicles”
[gene for this molecular regulatory function]
PAX-2
Regulates transformation of “Renal Vesicles” into Convolutes tubules & Loop of Henle
[gene for this molecular regulatory function]
WNT-4
Induce branching & growth of URETERIC BUD into ureter renal pelvis, major & minor calyces & even collecting tubules of Bellini
[gene for this molecular regulatory function]
GDNF(ret) + HGF(met)
