14-02 ALL EMBRYO II 2018 - Urinary

Question 1

urinary bladder with trigone

[anong embryonic origin nitong adult deriative na ‘to?]

Answer 1

upper wide 3rd of urogenital sinus

Question 2

loop of Henle

[anong embryonic origin nitong adult deriative na ‘to?]

Answer 2

metanephros (metanephric blastema)

Question 3

penile phallic urethra

[anong embryonic origin nitong adult deriative na ‘to?]

Answer 3

lower longer 3rd of urogenital sinus

Question 4

major and minor calyces

[anong embryonic origin nitong adult deriative na ‘to?]

Answer 4

ureteric bud

Question 5

prostatic & membranous urethrae of male

[anong embryonic origin nitong adult deriative na ‘to?]

Answer 5

mid constricted 3rd of urogenital sinus

Question 6

minor calyx

[anong ANLAGEN nitong ADULT DERIVATIVE na ‘to?]

Answer 6

ureteric bud

Question 7

renal pelvis

[anong ANLAGEN nitong ADULT DERIVATIVE na ‘to?]

Answer 7

ureteric bud

Question 8

major calyx

[anong ANLAGEN nitong ADULT DERIVATIVE na ‘to?]

Answer 8

ureteric bud

Question 9

loop of Henle

[anong ANLAGEN nitong ADULT DERIVATIVE na ‘to?]

Answer 9

Blastema

Question 10

Bowman’s Capsule

[anong ANLAGEN nitong ADULT DERIVATIVE na ‘to?]

Answer 10

Blastema

Question 11

A 2-day patient has a presenting sign of ambiguous external genitalia with enlared abdomen with palpable mass 7x10.5cm at the back extending to the lumbar area, left. patient was subjected to abdominal ultrasound which reveals the following pertinent results: (+) to consider Wilm’s Tumor, left (+) Polycystic Xidney Disease, right. While, the rest of the Complete Physical Examination findings are within normal findings. What’s your initial impression?

Answer 11

Denys-Drash Syndrome

Question 12

Autosomal Recessive Congenital Polycystic Kidney Disease

Answer 12

most often leads to early & emergency dialysis secondary to renal failure

Question 13

The following leads to “ascent of the kidneys” EXCEPT:

a. lumbosacral vertebral bodies’ growth & enlargement
b. development of thoracic & sacral spinal curvatures
c. complete fibrous obliteration of allantois to urachus
d. regression of mesonephros

Answer 13

c. complete fibrous obliteration of allantois to urachus

Question 14

“The definitive adult-type of kidney” anlage:

Answer 14

metanephros

Question 15

Chromosome 10q24.3-25.1 is:

Answer 15

PAX-2

Question 16

blocks apoptosis that delays canal between Bellini & forming nephron

[GENE for this regulatory function]

Answer 16

BMP-7

Question 17

“scatter factor” is recognized by this proto-oncogene receptor

[GENE for this regulatory function]

Answer 17

met

Question 18

regulates transformation of blastemal caps into renal vesicles

[GENE for this regulatory function]

Answer 18

PAX-2

Question 19

master gene for “kidney formation” in a very regulated expressions

[GENE for this regulatory function]

Answer 19

WT-1

Question 20

regulates transformation of renal vesicles into renal tubules

[GENE for this regulatory function]

Answer 20

WNT-4

Question 21

segmentation of pronephros into 7-10 cell masses

[GENE for this regulatory function]

Answer 21

PAX-1

Question 22

BLOCK apoptosis & allow proliferation of nephron

[GENE for this regulatory function]

Answer 22

BMP-7 & FGF-2

Question 23

INDUCE branching of ureteric bud into calyces

[GENE for this regulatory function]

Answer 23

GDNF & Scatter factor

Question 24

Master gene for blastema becoming “the KIDNEY”

[GENE for this regulatory function]

Answer 24

WT-1

Question 25

regulates renal vesicles into tubules & Henle [GENE for this regulatory function]

Answer 25

WNT-4

Question 26

regulates blastemal cap into renal vesicles [GENE for this regulatory function]

Answer 26

PAX-2

Question 27

mutated gene for Melnick-Fraser Syndrome [GENE for this regulatory function]

Answer 27

EYA-1

Question 28

mutated gene for Townes-Brocks Syndrome [GENE for this regulatory function]

Answer 28

SALL-1

Question 29

HGF's proto-oncogene receptor [GENE for this regulatory function]

Answer 29

Met

Question 30

GDNF's proto-oncogene receptor [GENE for this regulatory function]

Answer 30

Ret

Question 31

ductuli deferentes; epididymis; paradidymis vas deferens; seminal vesicle; ejaculatory ducts [Anlagen for these derivatives]

Answer 31

Wolffian Duct

Question 32

Fallopian Tubes; uterus upper 3rd of vagina [Anlagen for these derivatives]

Answer 32

Müllerian duct

Question 33

Phallic urethra of penis [Anlagen for these derivatives]

Answer 33

Lower longer 3rd of urogenital sinus

Question 34

urinary bladder [Anlagen for these derivatives]

Answer 34

upper wide 3rd of urogenital sinus

Question 35

membranous urethra of male [Anlagen for these derivatives]

Answer 35

mid constricted 3rd of urogenital sinus

Question 36

Henle's loop; proximal and distal convoluted tubules; Bowman's capsules [Anlagen for these derivatives]

Answer 36

Blastema

Question 37

Ureters; renal pelvis; major and minor calyces; Malphighii pyramids, collecting tubules of Bertin [Anlagen for these derivatives]

Answer 37

ureteric bud

Question 38

Median umbilical ligament [Anlagen for these derivatives]

Answer 38

urachus of allantois

Question 39

external urethral meatus of glans penis [Anlagen for these derivatives]

Answer 39

epithelial solid cord tag

Question 40

pronephros; rhesonephrosl & metanephros [Anlagen for these derivatives]

Answer 40

Intermediate mesoderm

Question 41

master gene for METANEPHROS or BLASTEMA becoming the Adult Definitive Type of KIDNEY SYSTEM [gene for this molecular regulatory function]

Answer 41

WT-1

Question 42

Blocks "apoptosis" or any caspase action which allows proliferation of nephron [gene for this molecular regulatory function]

Answer 42

BMP-7 + FGF-2

Question 43

Regulates blastemal caps' transformation into "Renal Vesicles" [gene for this molecular regulatory function]

Answer 43

PAX-2

Question 44

Regulates transformation of "Renal Vesicles" into Convolutes tubules & Loop of Henle [gene for this molecular regulatory function]

Answer 44

WNT-4

Question 45

Induce branching & growth of URETERIC BUD into ureter renal pelvis, major & minor calyces & even collecting tubules of Bellini [gene for this molecular regulatory function]

Answer 45

GDNF(ret) + HGF(met)