11. Gluconeogenesis Flashcards

1
Q

Glucogeno heparico

A

Sirve en 24horas

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2
Q

Deficiencia de enzimas gluconeogenicas

A

Hipoglucemia

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3
Q

Precursores gluconeogenicos

A

Glicerol
Lactato
α-cetoacidos

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4
Q

Aminoácidos no glucogenicos

A

Leucina y lisina

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5
Q

Glicerol viene de

A

Hidrolisis de TAG

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6
Q

Glicerol cinasa

A

Fosforila glicerol a glicerol 3-fosfato

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7
Q

Glicerol 3- fosfato a digphidroxiacetoma fosfato por

A

Glicerol 3 fosdato deshidrogenasa

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8
Q

Lactato oxidado a piruvato

A

Ciclo de cori

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9
Q

Hidrolisis de proteinas en ayuno dan

A

α-cetoacidos(piruvato)

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10
Q

Compuestos que dan CoA

A

Acetoacetato
Lisina
Leucina

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11
Q

Precursor directo de PEP

A

OAA

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12
Q

PEP a Piruvato

A

Reaccion irreversible por piruvato cinasa (PK)

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13
Q

Piruvato carboxilasa (PC)

A

Piruvato a OAA

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14
Q

OAA a PEP por

A

PEP-Carboxicinasa (PEPCK)

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15
Q

Piruvato carboxilasa requiere

A

Biotina como coenzima

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16
Q

Biotina se une a

A

Grupo ε - amino de lisina

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17
Q

Se hidroliza ATP para

A

Carboxilar piruvato a OAA

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18
Q

Reaccion de piruvato carboxilasa

A

En mitocondrias de hepatocitos y renales

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19
Q

CO2 viene de

A

HCO3 para transferirse a grupo prostetico de biotina

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20
Q

CO2 + Piruvato da

A

OAA

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21
Q

Oxalacetato se hace malato para

A

Atravesar menmbrana mitocondrial

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22
Q

Malato se reoxida en citosol a

A

Oxalacetato

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23
Q

El OAA se descarboxla por PEPCK a

A

Fosfoenolpiruvato(PEP)

24
Q

Carboxilasas que requieren biotina

A

PC
AcetilCoA Carboxilasa
Propionil CoA carboxilasa
Metilcrotonil CoA carboxilasa

25
PC se activa alostericamente por
Acetil CoA
26
Elevado Acetil CoA
En ayuno
27
OAA a malato por
Malato deshidrogenasa(MD)
28
Malato a OAA se reoxida por
Malato deshidrogenasa citosolica
29
En reoxidacion de OAA
El NAD se reduce a NaDH
30
OAA puede convertirse a
PEP | Aspartato
31
GTP impulsa
OAA a PEP
32
Hidrolisis de fructosa 1,6 bifosfato por
Fructosa 1,6 bisfosfatasa
33
PKF-1 inhibida por
Fructosa 1,6 bisfosfato
34
Glucagon aumenta
AMPc que activa Proteina cinasa A
35
Proteina cinasa A fosforila
PFK-2 inactivandola
36
PFK-2 inactivada activa a
FBP-2 que crea fructosa 6-fosfato
37
FBP-1 hace frectosa 6-fosfato
Desfosforilando fructosa 1,6 bisfosfato
38
Fructosa 1,6 bisfosfatasa(FBP-1) se inhibe oor
AMP/ATP(baja energia)
39
Altos ATP impulsan
Gluconeogenesis
40
Fructosa 2,6 bisfosfato inhibe
Fructosa 1,6 bisfosfatasa(FBP-1)
41
Glucosa 6-fosfatasa por hidrolisis
Desfosforila glucosa 6-fosfato
42
Glucosa 6 fosfato a traves de RER por
Glucosa 6 fosfato translocasa
43
Produce glucosa libre
Glucosa 6-fosfatasa
44
Almacenamiento de glucogeno por deficiencia de
Fosfatasa(1a) y traslocasa(1b)
45
Reacciones irreversibles de gluconeogenesis
Hexicinasa/glucosijasa PFK-1 PK
46
Regulacion de gluconeogenesis por
Glucagon | Sustratos glucogenicos
47
Glucagon disminuye
Fructosa 2,6 bifosfato(activando FBP-1 e inhibiendo PFK-1)
48
Glucagon unido a proteina G
Suelta AMPc inactivando PK( fosforilada)
49
Glucagon incrementa
Trascripcion de gen lara PEPCK
50
Cortisol incrementa
Trascripcion de gen de PEPCK
51
Activacion en ayuno de PC hepatica por
AcetilCoA
52
Acetil CoA inhibe
PDHC( activando PDH cinasa)
53
FBP-1 inhibida por
AMP y activa PFK-1
54
Complejo PDH con AcetilCoA
Mo entra a ciclo d krebs
55
Piruvato con piruvato carboxilasa
Se hace OAA que da Glucosa