11. 9 skin Flashcards
skin functions
thermoregulation, protection, gives sensory input, excretion, blood reservoic and makes vit D
thermoregulation
Blood can be shunted away capillaries of skin
to reduce heat loss. Hairs can be erected (piloerection) via sympathetic stimulation to trap
insulating air next to skin.
Note that ‘goosebumps’ (piloerection reflex) can occur when cold
or in response to stress/emotion (fxn in human ancestors [vestigial reflex] may have been to
make them appear larger to scare off predators.
Immunity: through skin
specialized cells of the epidermis are components of immune system
Blood reservoir: skin
Vessels in the dermis hold up to 10% of the blood in resting adult
Vit D synthesis: skin
UV radiation activates skin molecule that is a precursor to Vit D
epidermis layers
corneum, lucidum, granulosum, spinosum, basale
top—-> bottom
COME LET’s GET SUN BURNED
Stratum corneum
25-30 dead layers (variable thickness); filled w/ keratin and
surrounded by lipids
i. Lamellar granulues make it water repellent
Stratum lucidum –
only in palms and soles of feet, and finger tips; 3-5 layers, clear/ DEAD
Stratum granulosum
3-5 layer of dying cells; lamellar bodies release hydrophobic lipids HERE
Stratum spinosum
strength and flexibility; 8-10 layers held together by (desmosomes-keratin involving adhesion proteins)
- also have Langerhans cells here
Stratum basale
(germinativum) – deepest layer. contains Merkel cells and stem
cells that divide to produce keratinocytes; attached by basement membrane. Melanocytes are found here.
** rapid division of cells
Keratinocytes:
produce the protein keratin that helps waterproof the skin. As they
are pushed up to top layer of skin they accumulate keratin and die, losing their
organelles along the way. Keratin is most abundant protein in epidermis.
Melanocytes:
transfer skin pigment melanin to keratinocytes
- Langerhans cells:
interact with helper T-cells of immune system
Merkel cells:
attach to sensory neurons and fxn in touch sensation