1-3. Inflammation/ Neoplasia Pathoma Flashcards
What CD receptor do neutrophils express
CD14
What role does PGI have
PGI = Platelet gathering inhibitor
What role do Mast Cells have
Release HistamineVasodilation and increase vascular permeability
What is the second phase response of Mast Cells
Recruit Leukotrienes
4 Mediators that call in Neutrophils
LTB4, C5A, IL-8, bacteria products
Classical compliment system
(ig) GM makes Classic cars (C1)
Pathway/end result of compliment system
C3, C5, generation of membrane attack complex (MAC)
What components of compliment system trigger mast cell degranulation
C3a and C5a
one role of C5 in the compliment system
Calls in neutrophils
What does bradykinin do?
Same thing as histamineincrease vasodilation, vascular permeability (++pain)
Prostaglandin E2
E2fEEEEEver and pain
mediators that macrophages release
TNF-g, IL-1Stimulate cox for PGE2for fever
Leukocyte migration and rollingwhat are the binding factors
E-selectin, P-selectinBinds the Sialyl-Lewis
Leukocyte adhesion of vessel wall
ICAM (intercellular adhesion molecule)
Delayed separation of umbilical cord
Leukocyte adhesion deficiency (LAD)CD18
Lack of pus formation
Leukocyte adhesion Deficiency
Impaired phagolysosome formation
Chediak-Higashi
Whats the mechanism of O2 to HOCl (bleach) in a phagocyte degredation
O2 –> O2- –> H2O2 –> HOCL
What is the defect in Chronic Granuloma Dz (CGD) aka poor O2 dependent killing
Defect in NADPH
Maturation process of T cells. where they from and where do they go?
T cells are made in the bone marrow and mature in the thymus
Which T cells recognize which MHC class
CD4 t cells recognize MHC class 2CD8 t cells recognize MHC class 1
CD4+ T cell activation requires what?(2 signals involved in activation)And what is their role
Antigen presenting cells (APCs) phagocytize antigen, process it, then present it on its MHC 2 membrane//B7 (on APC) binds to CD28 on MHC2CD4 release cytokines to help in inflammation
What do CD4 helper T cells do?
They help both CD8+ / BcellsBroken into 2 subsetsTh1 helps CD8Th2 helps with B cells
Th1 helps what cells and how?
Th1 helps CD8 cellsby releasing IL-2 (t cell growth factor and activator) and IFN-g (macrophages)
