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MT6317 > 02 CREATINE & CREATININE > Flashcards

02 CREATINE & CREATININE Flashcards

1
Q

The plasma creatinine level is ___ proportional to the GFR

A

inversely

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2
Q

Used in the diagnosis of muscle disease in place of creatine

A

Creatine kinase

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3
Q

Muscle dystrophy causes plasma creatine to ___ (increase/decrease) and urinary creatinine to ___ (increase/decrease)

A

increase
decrease

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4
Q

Poliomyelitis causes plasma creatine to ___ (increase/decrease) and urinary creatinine to ___ (increase/decrease)

A

increase
decrease

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5
Q

Hyperthyroidism causes plasma creatine to ___ (increase/decrease) and urinary creatinine to ___ (increase/decrease)

A

increase
decrease

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6
Q

Creatinine is a waste product of ___ formed during normal muscle metabolism

A

creatine

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7
Q

Creatine is produced by the liver and pancreas from ___, ___, ___

A

arginine
glycine
methionine

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8
Q

Creatine phosphate loses ___ and creatine loses ___ to form creatinine

A

phosphoric acid
water

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9
Q

T/F: plasma creatine levels are increased in renal disease

A

F (not elevated)

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10
Q

A measure of the amount of creatinine eliminated from the blood by the kidneys

A

Creatinine clearance (CrCl)

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11
Q

Normal range of CrCl in males

A

97-137 mL/min

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12
Q

Normal range of CrCl in females

A

88-128 mL/min

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13
Q

Plasma creatinine is sensitive only if the renal dysfunction is at ___%

A

> 50%

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14
Q

An analyte measured in the blood that is a more sensitive measure than plasma creatinine and is able to detect mild renal dysfunction

A

Cystatin C

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15
Q

Gold standard for creatinine clearance determination

A

Inulin clearance

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16
Q

CrCl is usually reported in units of ___ and can be corrected for body surface, which is ___

A

mL/min
173

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17
Q

T/F: in MDRD and Cockgroft-Gault equations, 24h urine are needed

A

F

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18
Q

Factors considered in the Cockgroft-Gault equation

A

Age
Weight
Sex (for women, multiply by 0.85)

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19
Q

Factors considered in the MDRD study equation

A

Age
Sex (for women, multiply by 0.742)
Race (for Africans, multiply by 1.21)

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20
Q

The chemical method for creatinine determination

A

Jaffe Reaction

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21
Q

Absorbance of the red-orange tautomer in the Jaffe reaction

A

520 nm

22
Q

Positive interferences in the Jaffe method of creatinine determination

A

Acetoacetic acid
Pyruvic acid
Ascorbate
Acetone
Glucose

23
Q

Adsorbents used to enhance the accuracy of Jaffe method of creatinine determination

A

Lloyd’s reagent
Fuller’s earth

24
Q

Component of Lloyd’s reagent

A

Sodium aluminum silicate

25
Q

Component of Fuller’s earth

A

Sodium magnesium silicate

26
Q

Used to isolate creatinine from noncreatinine chromogen

A

Aluminum silicate

27
Q

Positive interferences in the kinetic Jaffe reaction

A

Alpha-ketoacids
Cephalosporins

28
Q

Negative interferences in the kinetic Jaffe reaction

A

Bilirubin
Hemoglobin

29
Q

The creatinine determination method that uses reagent strips and produces purple-colored compound

A

3,5-Dinitrobenzoic acid Method (DNBA)

30
Q

DNBA is measured at what wavelength?

A

560 nm

31
Q

For the automated determination of creatinine level and forms orange-red complex

A

alkaline 3,5 dinitrobenzoate solution

32
Q

Alkaline 3,5 dinitrobenzoate solution is measured at what wavelength?

A

546 nm

33
Q

Specimens used for creatinine determination

A

Plasma
Serum
Urine

34
Q

In using urine for creatinine determination, what must be done?

A

Refrigerated after collection or frozen if longer storage than 4 days

35
Q

T/F: in Jaffe method, ascorbate falsely decreases while in the enzymatic method, it falsely increases

A

F (Jaffe = false increase, enzymatic = false decrease)

36
Q

In creatinine determination, ___ causes negative bias in both Jaffe and enzymatic methods

A

Bilirubin

37
Q

Lidocaine causes a ___ bias in some enzymatic method of creatinine determination

A

positive

38
Q

Normal range of creatinine for adult male (Jaffe)

A

0.9-1.3 mg/dL

39
Q

Normal range of creatinine for adult female (Jaffe)

A

0.6-1.1 mg/dL

40
Q

Normal range of creatinine for children (Jaffe)

A

0.3-0.7 mg/dL

41
Q

Normal range of urine creatinine for adult male (Jaffe)

A

800-2000 mg/dL

42
Q

Normal range of urine creatinine for adult female (Jaffe)

A

600-1800 mg/dL

43
Q

Normal range of creatinine for adult male (enzymatic)

A

0.6-1.1 mg/dL

44
Q

Normal range of creatinine for adult female (enzymatic)

A

0.5-0.8 mg/dL

45
Q

Normal range of creatinine for children (Enzymatic)

A

0-0.6 mg/dL

46
Q

A chemical method of creatinine determination based on Jaffe reaction wherein creatinine in protein-free filtrate reacts with alkaline picrate to form colored complex

A

Folin-Wu method

47
Q

T/F: Jaffe reaction with adsorbent is not routinely used because it is time consuming and not readily automated

A

T

48
Q

A creatinine determination method that is routinely performed and is inexpensive, rapid, and easy to perform

A

Jaffe kinetic

49
Q

A creatinine determination method that is adapted for used as dry slide method

A

Creatininase-H2O2

50
Q

T/F: Creatininase-H2O2 can potentially replace Jaffe method

A

T

51
Q

Wavelength used in Jaffe kinetic method of creatinine determination

A

520 nm

52
Q

Conversion factor of creatinine from conventional to SI unit

A

88.4

MT6317 (18 decks)

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