week 9 patho seizures Flashcards

1
Q

what is the resting membrane potential

A

-70 to -80 mv

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2
Q

how do elements contribute to depolarisation

A
  • calcium and sodium come in, potassium leaves
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3
Q

what are the two main neurotransmitters responsible for brain excitation

A

acetylcholine and glutamate (excitatory)

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4
Q

which neurotransmitters cause inhibition

A

dopamine and GABA (inhibitory)

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5
Q

whats the difference between seizure and epilepsy

A

seizure is an abnormal sudden electrical discharge of neurons that can result in seizure
epilepsy is a chronic disorder in which repeated unprovoked seizure activity occurs

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6
Q

what are the three broad categories of seizures

A

generalised seizures, focal onset seizures, unclassified seizures

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7
Q

seizures characterised by a loss of consciousness and last for 5 minutes are

A

tonic clonic

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8
Q

which seizure has a person staring blank and unresponsive for 5-10 seconds

A

absence

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9
Q

which type of seizure is brief jerking of extremities often right after waking up or going to bed

A

myoclonic

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10
Q

which seizure is the one where they literally just fall over

A

atonic

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11
Q

which seizure is the one where something weird randomly just happens to them but theyre super aware (i.e. cant speak)

A

focal aware seizure

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12
Q

which type of seizure is the one where they appear to be awake but are absent and have automatism behaviour

A

focal impaired

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13
Q

what are focal seizures

A

partial seizures where only one part of the brain is involved.

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14
Q

what are the main triggers for seizures

A

stress, lack of sleep, hormones, stimulation, fever mainly

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15
Q

what are the seizure stages

A
  1. prodrome: days to hours before seizure patient has changes in mood
  2. aura: early part of seizure (smell things, visual changes)
  3. Ictal phase: the actual seizure
  4. postictal: patient is likely confused, exhausted, muscle aches, injuries
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16
Q

what are the 5 big consequences of seizures

A
  • aspiration
  • impaired gas exchange
  • injury
  • quality of life
  • mental health
17
Q

what is status epilepticus

A

seizure for over 5 mins or repeated seizures for over 30 mins, this is a medical emergency

18
Q

why is status epilepticus so bad

A

because the brain needs more metabolism during this time (O2, glucose, etc)
the brain can go info hypocxemia, hyperthermia, resp failure, cardiac arrest

19
Q

how does status epilepticus cause renal failure (rhabomyolysis)

A

because it can cause muscle breakdown which causes myoglobin accumulation in the kidneys