week 12 pharm part 2 (actual drugs) Flashcards
what are the two antimetabolites
methotrexate
fluorouracil
what are the two antitumout antibiotics
doxorubicin
bleomycin
what are the two mitotic inhibitors
vincristine
paclitaxel
what is the alkylating agent
cyclophosphamide
what is the MOA of cyclophosphamide
it causes alkylation of DNA which destroys DNA in cancer cells and prevents them from being able to repair themselves
which phase does cyclophosphamide act on
any phase of the cell cycle
what is a unique adverse effect of cyclophosphamide
may cause bladder injury
what is the MOA of methotrexate
it inhibits folic acid which is required for DNA and RNA synthesis
which phase of the cell cycle does methotrexate act on
S phase
what is a unique adverse effect of methotrexate
pulmonary fibrosis
what is leucovorin rescue
its a drug used to enhance the effects of methotrexate while reducing harm to normal cells.
can also be adjunct with fluorouracil
what enzyme does fluorouracil inhibit
thymidylate syntehtase
which type of tumours do fluorouracil treat
solid tumours (with surgery and radiation as well)
what phase of the cell cycle does fluorouracil act on
s phase
between doxorubin and bleomycin, which drug will injure the lungs and which may injure bone marrow and heart
doxorubin: myelosuppression and heart damage
bleomycin: lung injury