Week 9 Flashcards
Endocrine cells
secretes hormones into blood
Nerve and endocrine cells - interaction
work together to ensure proper functioning of body system
Nerve and endocrine cells - communication
most intercellular communication takes place by chemical signals that travel to another cell
Target cell
cell that signal molecules bind to in order to trigger response
Nerve control
fast and quick
impulses are delivered to highly defined target cells
Endocrine control
slow and last a long time in the blood, can alter gene transcription
broadcast to all cells potentially
Nervous system functions
controls movement of skeletal muscles
Endocrine system function
controls prolonged activities
Paracrines
chemicals secreted by one cell that affects neighbouring cells
Autocrines
chemicals that are secreted into intercellular fluids that diffuse to receptors on very same cell
Hormones
carried throughout the body by blood circulation
Neurotransmitters
move across the synaptic cleft, secretion may be controlled by impulses that originated far from release site
Pheromones
released into environment and affect other individuals
Exocrine glands
secrete substances into a duct or body cavity
Endocrine cells
secrete substances into blood
Hormone
chemical substance, secreted into blood by endocrine cells that regulate the function of other cells
act at very low blood concentrations
Neurosecretory cells
resemble neurons
propagate action potentials
cell bodies are in CNS
direct interface between nervous and endocrine system
Nonneural endocrine cells
stimulated to secrete hormones by other hormones
Peptide and protein hormones
water soluble and easily transported in blood
packages in vesicles and released to blood by exocytosis
cant cross cell membrane
Steriod hormones
synthesised from cholestrol lipid soluble, bound to carrier proteins in blood
Amine hormones
modified amino acids
may be lipid soluble or water soluble `
Hormone binding - on target cell surface
binds to part of the receptor protein outside membrane
many receptors are G protein linked
G protein linked receptors
initiate second messenger signaling cascades inside target cell
Hormone binding - inside target cell
lipid soluble hormones can diffuse through cell membrane
Negative and positive feedback effect on receptor proteins
can influence number of receptor protein per cell
negative feedback stabilizes concentration of hormones
Hormones - different cells
can have different effects
Peptide hormones - timing
synthesised prior to use and stored, can be released quickly
Steroid hormones - timing
usually synthesised on demand, initiation of secretion is slow
How hormones are removed from blood
liver and kidneys can degrade hormones enzymatically, or hormones are excreted
Peripheral activation
hormones are converted to more active forms after they are secreted
Pituitary gland
master gland
secretes hormones that control other glands
Posterior pituitary
extension of brain, hormones are synthesised and secreted by brain neurosecretory cells
Hypothalamus hormones
antiduirectic
oxytocin
antidiurectic hormone
controls water excretion of kidney
oxytocin
stimulates uterine contractions during birth and milk flow
Anterior pituitary - cells
hormones are synthesised by nonneural endocrine cells
Tropic hormones
tropins that control other endocrine glands
Adrenocorticotropin
controls adrenal cortex
Thyroid stimulating hormone
controls thyroid gland
LH and FSH
control gonads
Anterior pituitary hormones
Adrenocorticotropin Thyriod stimulating Lh FSH Growth hormone prolactin melanocyte stimulating
Growth Hormone
promotes growth