Week 7 Pharmacokinetics and Biopharmaceutics 3 Flashcards
1
Q
what does a negative log p mean
A
compound so water soluble that is not easily able to pass through the fatty membranes
2
Q
what does large log p mean
A
compound so water insoluble that difficult to into solution in order to approach the fatty membranes
3
Q
optimal log p value
A
2
4
Q
What is the pH partition hypotheis
A
we assume that only lipid soluble molecules are able to cross the GIT membranes
most drugs are weak electrolytes that can ionize to water soluble species
5
Q
Low pH affect on api
A
largely unionised this is not surprising as the concentration of H+ in solution is high so the acid groups of the apis cannot dissociate
6
Q
Why is optimal Log P
A
Optimal activity is at index of biological activity
