GIT Therapeutics Flashcards

1
Q

what is coeliac disease

A

auto immune disorder which is the inability to ingest gluten. Protein found in wheat, barley and rye. which is formed from gliadin and glutenin.

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2
Q

what can coeliac disease cause

A

damages to the small intestine

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3
Q

what is the immune response when a coeliac eats gluten

A

attacks small intestine making it harder to absorb nutrients and can often lead to comorbidities such as anaemia

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4
Q

what is a comorbiditity

A

comorbidity is the presence of one or more additional conditions often co-occurring with a primary condition.

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5
Q

What possible symptoms exist for cealiac

A

occasional or excessive diarrhoea

persistent or unexplained GI symptoms such as nausea vomiting

reccurent stomach pain, bloating , cramps

headaches and or tiredness

sudden weight loss

mouth ulcers

tooth enamel problems

skin rashes depression

depression

iron deficient anaemia

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6
Q

what will a doctor initially recommend on the arrival of a suspected coeliac

A

serological testing where the tissue transglutaminase lgA test is carried out and should be offered to those with diagnosis of IBS, test is available in pharmacy but not diagnostic

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7
Q

what treatment is there for coeliacs

A

life long adherence to a strictly gluten free diet,

avoid foods containing wheet, barley and rhy

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8
Q

what does ibs stand for

A

irritable bowel syndrome

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9
Q

what is a disease

A

characterized by an identifiable group of signs, symptoms, or both. Underlying causes normally identified including infection, inflammation, external factors, genetic defects

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10
Q

what is a syndrome

A

group of symptoms that collectively indicate or characterize a disease, psychological disorder, or other abnormal condition

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11
Q

What type of disorder can ibs be classified as

A

functional disorder

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12
Q

what is IBD

A

inflammatory bowel disease which refers to chrons dicease and ulcerative colitis

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13
Q

what causes ibs

A

there is no known cause of it

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14
Q

what are some suggestions for ibs causes

A
drugs (antibiotics)
food
Gi surgery
Ovarian hormones
Fat
Lack of fibre
GI infections
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15
Q

Symptoms of IBS

A

abdominal pain / cramps relieved by going to the toilet

bloating and constipation

urgency to get to the toilet

alternate constipation and diarrhea

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16
Q

what is not an indicator of IBS

A

blood in stools

17
Q

when do we diagnoze IBS

A

abdominal pain or discomfort

bloating

change in bowel habit

ABC > 6 months

18
Q

what criteria must be formed before a diagnosis is formed

A

2 of the 3 abc
relief from defecation
stool form or frequency

19
Q

what lifestyle advice can be given to someone who has IBS

A

8 cups of fluid per day of water or a herbal tea

review fibre intake (reduce)

limit fresh fruit (3 portions per day)

limit caffinated alcohollic and fizzy drinks

20
Q

how can we manage ibs pharmacologically

A

antispasmoids

laxatives for constipation

loperamide for diarrhoe

21
Q

how can we manage ibs pharmacologically 2nd line

A

tricyclic antidepressants
SSRIs
Psychological interventions

22
Q

what is dyspepsia

A

general term for pain in the upper gastrointestinal tract e.g. heartburn

best described as a symptom of other GI conditions

23
Q

what is gastro oesophageal reflux disease (GORD)

A

The symptoms and/or mucosal injury due to abnormal reflux of gastric contents in the oesophagus

24
Q

what are some typical gord symptoms

A

heartburn
waterbrash
dysphagia

25
Q

how can we treat gord

A

anatacids which are salts of calcium magnesium and aluminium which help to neutralise stomach pH

26
Q

what is gastritis

A

inflammation of the gastric mucosa

27
Q

how can a gastritis diagnosis be confirmed

A

endoscopic examination

28
Q

what are the two site for treating dyspepsia

A

histamine 2 receptor antagonists

proton pump inhibitors

29
Q

what is histamine used to treat

A

mild to moderate gord

30
Q

what are the main unwanted effects of histamines

A

diarrhoea
dizziness
muscle pain
cimetidine can decrease male sexual function and interact with anticoagulants and tricyclic antidepressants