Crystals 1 Flashcards
What are the most widely used dosage form
tablets, capsules
What form are most API’s in the form of
Powders
What are the powders correlated with
underlying solid state structure of the material
What does solubility depend on
crystal structure
what does dissolution depend on
solubility
What can bioavailability depend on
dissolution rate
what is solubility
max amount of solute dissolved per unit volume of solvent
What is dissolution
solid dissolves to form a solution process proceeds until cs reached.
What are crystalline materials are characterized by
long range order
What are amorphous materials characterized by
a lack of long range order
Form State in order of mobility
Gas Liquid Amorphous Solid Crystalline Solid
What are polymorphs
different three dimensional packing arrangements of the same object
What holds a solid together
electrostatic interaction
hydrogen bond
dipole dipole
dispersion
