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Journey through GI > Powders 9 > Flashcards

Powders 9 Flashcards

1
Q

What are the three steps of tablet formation

A

filling
compression
ejection

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2
Q

how do we calculate compression force

A

we add attrition force to the reaction force

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3
Q

what are the two main sources of friction between particles

A

Friction between particles

Friction between material and die wall lubricants are used to reduce this effect

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4
Q

Which part of friction do glidants reduce

A

friction between particles

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5
Q

which part of friction do lubricants reduce

A

friction between material and die wall

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6
Q

what do the forces applied during compression affect

A

the content

the container

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7
Q

what effect does force have on the content

A

pore number decreases
pore size decreases
mechanical strength of the compressed mass increases
tendency of the compressed mass to disaggregate decreases

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8
Q

Describe the different stages a tablet would go through as the compression force increases

A

Repacking of particles

elastic or plastic deformation at contact points

powder or granules fragmentation and formation of new surfaces as the contact area is increased

cohesion between particles

elastic or plastic deformation of the solid mass

tablet ejection

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9
Q

What are the different forms of tablets

A 
uncoated
coated
effervescent 
soluble
dispersible
orodispersible
gastro resistant
modified release
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10
Q

what are the common quality control tests

A 
uniformity of content
uniformity of mass
disintegration
dissolution
resistance to crushing
friability
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11
Q

what is the purpose of tablet coating

A

mask taste + color

physically or chemically protect the ingredients

incorporate another drug in the coating to avoid chemical incompatibilities or to provide sequential drug release.

favor swallowing

improve mechanical strength of a tablet

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12
Q

What prerequisites must be met before a tablet can be coated

A

resistance to abrasion and rupture
shape must round or spherical
appropriate chemico physical characteristics

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13
Q

what are the 3 different types of coating

A

sugar
film
press

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14
Q

Describe the 6 steps of sugar coating

A

sealing of tablet cores

subcoating

smoothing

colouring

polishing

printing

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15
Q

What would a film coating contain

A

polymer, ethers of cellulose or other polymers

plasticizers

colourants

solvents

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16
Q

what are the 4 advantages of film coating over sugar coating

A

less volume increase

better stability of the tablet

better mechanical strength

one step process

Journey through GI (30 decks)

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