Week 5: Parasitology Flashcards

1
Q

What is a parasite?

A

An organism that lives on or in an organism and gets its food from or at the expense of host

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2
Q

What is a vector?

A
  • A living transmitter of disease
  • involved in essential steps of the parasitic life cycle
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3
Q

What is a parasite reservoir?

A
  • Sources of parasites in the environment
  • could be ecological system where an infectious agent survives indefinately
  • Includes all the component host populations including that of any intermediate host or vector
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4
Q

What is a definitive host?

A
  • Host in which parasites have sexual reproduction
  • Primary host
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5
Q

What is the intermediate host?

A

Host in which parasites asexually reproduce or do not reproduce at all but do develop into a new stage

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6
Q

What is an incidental host?

A
  • Host that is infected but not required for the maintenance of the population
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7
Q

Features of Protozoa

A
  • Single-celled Eukaryotes
  • Replication inside the host
  • Trophozoite
    • active form
    • replicates by binary fission
  • Cyst
    • Dormant, non-replicative form
    • Protected by double-membranes
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8
Q

Features of Helminths

A
  • Multicellular Animals
  • Complex life-cycles
    • do not complete life cycle within a single human host
  • Reproduce sexually
  • May form cysts
    • protected by an impermeable cuticle
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9
Q

Features of Amoebas

A
  • Psuedopod used for motility
  • Alternate between trophozoite & cyst forms
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10
Q

Features of Flagellates & Ciliates

A

Use flagella or cilia for locomotion

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11
Q

Features of sporozoa

A
  • Gliding motility
  • Intracellular replication
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12
Q

Types of protozoa parasites

A
  • Amoeba
  • Flagellates & Ciliates
  • Sporozoa
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13
Q

Examples of protoza locomotion

A
  • Giardia lamblia trophozoite “falling leaf”
  • Cryptosporidium sporozoite gliding motion
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14
Q

Protozoa reproduction

A
  • Asexual reproduction
  • Trophozoite form reproduces by binary fission inside host
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15
Q

Categories of helminths

A
  • Nematode (Roundworm)
  • Trematode (Flatworm)
  • Cestode (Tapeworm)
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16
Q

Nematode reproduction

A
  • Most are dioecious: sexes are separate
  • Some are hermaphroditic
17
Q

Trematode reproduction

A
  • Hermaphroditic
    • includes both male and female gonads & generates both sperm and eggs
  • Can reproduce sexually or asexually
    • sexually self- or cross-fertilization
    • Asexually (break off half)
18
Q

Cestode reproduction

A
  • Hermaphroditic
  • can reproduce sexually or asexually
19
Q

What is the infective dose and exposure

A
  • specific route of exposure
  • infection does not always result in disease
20
Q

Describe the penetration of anatomical barriers

A
  • Direct penetration through skin or via arthropod vectors
  • Oral ingestion
21
Q

Describe attachment to specific host cells or organs

A
  • Tissue tropism facilitated by parasite surface adhesins and glycoprotein or glycolipid receptors on some cell types
22
Q

Factors associated with pathogenicity

A
  • Antigenic variation
  • Molecular mimicry
  • Masking
  • Intracellular location
  • Immunosuppression
    • suppression of parasite-specific B & T-cell responses
    • Degradation of immunoglobulins
23
Q

Possibly incomplete plasmodium factors of pathogenicity

A
  • Antigenic variation
  • Molecular mimicry
  • Intracellular location
  • Suppression of parasite-specific B & T-cell responses
24
Q

Incomplete Schistosoma factors of pathogenicity

A
  • Molecular mimicry
  • Masking
  • Degradation of immunoglobulins
25
Q

Incomplete trypanosoma factors of pathogenicity

A
  • molecular mimicry
  • Masking
  • intracellular location
  • Suppression of parasite-specfic B & T-cell responses
26
Q

What is masking

A

mimic host molecules to pretend to be part of the host

27
Q

Replication in the host occurs in

A

all protozoa but NOT all helminths

28
Q

Plasmodium falciparum unique factor of pathogenicity

A

toxin production

29
Q

Strongyloides unique factor of pathogenicity

A

hydrolytic enzymes

30
Q

Pathogens that cause mechanical tissue damage

A

Helminth larvae (migration through tissue)

Blockage of internal organs (cestodes)

31
Q
A