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Infectious Disease > Week 5: Infections in immunocompromised hosts > Flashcards

Week 5: Infections in immunocompromised hosts Flashcards

1
Q

When to think immune deficiency?

A
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2
Q

Common evaluation

A
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3
Q

Examples of infections in innate immune deficiency

A
  • Chronic granulomatous disease
  • Terminal complement deficiency (C5-9)
  • Netropenia
  • Leukocyte adhesion defects
  • Job’s Syndrome
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4
Q

Innate immune deficiency causes

A

Decreased chemotaxis, diminished phagocytic capacity & defective intracellular killing

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5
Q

Infective etiologies of innate immune deficiency

A

Hepatic abscesses

Skin infections

Gingivitis

Recurrent pyrogenic infections

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6
Q

Infectious organisms in innate immune deficiency

A
  • S. aureus
  • CoNS
  • viridans strep
  • enterococcus
  • E. coli
  • P. aeruginosa
  • Serratia
  • Aspergillus
  • Nocardia
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7
Q

Examples of humoral antibody deficiency

A
  • X-linked agammaglobulinemia
  • CVID
  • CLL
  • MM
  • Extensive RxTx
  • Chemo
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8
Q

humoral antibody deficiency Dx

A

Failure to make Ab to new Ag or even Ab after vaccines

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9
Q

Infectious etiologies of humoral antibody deficiency

A
  • Recurrent sinopulmonary infections with encapsulated organisms
  • Chronic diarrhea
  • Aseptic meningitis
  • Echoviruses
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10
Q

Infectious organisms of humoral antibody deficiency

A
  • Strep pneumo
  • H. influenzae
  • Giardia
  • Enteroviruses
  • Campylobacter
  • Shigella
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11
Q

Causes of Cellular immune deficiency

A
  • Digeorge Syndrome
  • Extensive irradiation
  • Immunosuppressives (Corticosteroids, cyclosporine, tactrolimus, monoclonal Ab)
  • Hoggkin’s Lymphoma
  • AIDS
  • CD4 lymphopenia
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12
Q

Infectious etiologies of Cellular immune deficiency

A
  • Intracellular organisms
  • viruses
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13
Q

Infectious agents of Cellular immune deficiency

A
  • Listeria
  • PJP
  • Nocardia
  • Mycobacteria
  • Histoplasma
  • Coccidiodomycosis
  • Aspergilius
  • Toxoplasma gondii
  • HSV
  • CMV
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14
Q

Causes of Asplenia immune deficiency

A
  • Splenectomy
  • Cirrhosis
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15
Q

Asplenia immune deficiency caused by

A

Reduced properdin so suboptimal opsonization

Low levels of circulating IgM

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16
Q

Infectious etiologies of Asplenia immune deficiency

A

Encapsulated organisms

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17
Q

Infectious agents of Asplenia immune deficiency

A
  • Strep pneumo
  • H. influenzae
  • N. meningiditis
  • Captocytophaga
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18
Q

Question

A

C.

E. coli

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19
Q

Question

A

B. Pseudomonas

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20
Q

Question

A
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21
Q

Question

A

E. Staph aureus

22
Q

Question

A
  1. Fusarium spp.
23
Q

Question

A

D. Chronic granulomatous disease

24
Q

Question

A

B. immunoglobulin levels

25
Question
C. Respiratory infection
26
Question
27
Question
A. Sever combined immunodeficiency
28
Question
D. Staphylococcus aureus
29
Question
C. Neisseria meningiditis
30
Question
D. Varicella zoster
31
Question
32
cell mediated 200
B. respiratory infections with encapsulated organisms
33
Functions of the neutrophil
34
Who has low or dysfunctional neutrophils?
35
Common syndromes associated with neutropenia
36
Things to remember considering neutropenia
37
How do we protect neutropenic patients?
38
Bottom-line of neutropenia
39
Initial management of fever and neutropenia
40
Question
41
Cell-mediated immunity
42
Who has dysfunctional cell-mediated immunity
43
What are the common syndromes associated with impaired cell-mediated immunity?
44
Common bacterial organisms associated with bacteria
* Listeria moncytogenes * Nocardia spp.
45
Common bacterial organisms associated with viruses
* Herpes viruses * CMV * Hep B and C
46
Common bacterial organisms associated with parasites
Toxoplasma gondii
47
Common bacterial organisms associated with fungus
* Histoplasma capsulatum * Coccidioides spp. * Cryptococcus spp. * Aspergillus spp, * Pneumocystis jirovecii
48
Common bacterial organisms associated with mycobacteria
* mycobacterium tuberculosis * nontuberculous mycobacterium
49
How do we protect patients with dysfunctional cell-mediated immunity
50
Question
51
Timeline of Hematopoietic Stem Cell Transplantation
52
Timeline of Hematopoietic Solid Organ Transplantation

Infectious Disease (82 decks)

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