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Infectious Disease > Week 5: Infections in immunocompromised hosts > Flashcards

Week 5: Infections in immunocompromised hosts Flashcards

1
Q

When to think immune deficiency?

A
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2
Q

Common evaluation

A
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3
Q

Examples of infections in innate immune deficiency

A
  • Chronic granulomatous disease
  • Terminal complement deficiency (C5-9)
  • Netropenia
  • Leukocyte adhesion defects
  • Job’s Syndrome
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4
Q

Innate immune deficiency causes

A

Decreased chemotaxis, diminished phagocytic capacity & defective intracellular killing

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5
Q

Infective etiologies of innate immune deficiency

A

Hepatic abscesses

Skin infections

Gingivitis

Recurrent pyrogenic infections

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6
Q

Infectious organisms in innate immune deficiency

A
  • S. aureus
  • CoNS
  • viridans strep
  • enterococcus
  • E. coli
  • P. aeruginosa
  • Serratia
  • Aspergillus
  • Nocardia
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7
Q

Examples of humoral antibody deficiency

A
  • X-linked agammaglobulinemia
  • CVID
  • CLL
  • MM
  • Extensive RxTx
  • Chemo
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8
Q

humoral antibody deficiency Dx

A

Failure to make Ab to new Ag or even Ab after vaccines

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9
Q

Infectious etiologies of humoral antibody deficiency

A
  • Recurrent sinopulmonary infections with encapsulated organisms
  • Chronic diarrhea
  • Aseptic meningitis
  • Echoviruses
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10
Q

Infectious organisms of humoral antibody deficiency

A
  • Strep pneumo
  • H. influenzae
  • Giardia
  • Enteroviruses
  • Campylobacter
  • Shigella
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11
Q

Causes of Cellular immune deficiency

A
  • Digeorge Syndrome
  • Extensive irradiation
  • Immunosuppressives (Corticosteroids, cyclosporine, tactrolimus, monoclonal Ab)
  • Hoggkin’s Lymphoma
  • AIDS
  • CD4 lymphopenia
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12
Q

Infectious etiologies of Cellular immune deficiency

A
  • Intracellular organisms
  • viruses
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13
Q

Infectious agents of Cellular immune deficiency

A
  • Listeria
  • PJP
  • Nocardia
  • Mycobacteria
  • Histoplasma
  • Coccidiodomycosis
  • Aspergilius
  • Toxoplasma gondii
  • HSV
  • CMV
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14
Q

Causes of Asplenia immune deficiency

A
  • Splenectomy
  • Cirrhosis
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15
Q

Asplenia immune deficiency caused by

A

Reduced properdin so suboptimal opsonization

Low levels of circulating IgM

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16
Q

Infectious etiologies of Asplenia immune deficiency

A

Encapsulated organisms

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17
Q

Infectious agents of Asplenia immune deficiency

A
  • Strep pneumo
  • H. influenzae
  • N. meningiditis
  • Captocytophaga
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18
Q

Question

A

C.

E. coli

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19
Q

Question

A

B. Pseudomonas

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20
Q

Question

A
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21
Q

Question

A

E. Staph aureus

22
Q

Question

A
  1. Fusarium spp.
23
Q

Question

A

D. Chronic granulomatous disease

24
Q

Question

A

B. immunoglobulin levels

25
Q

Question

A

C.

Respiratory infection

26
Q

Question

27
Q

Question

A

A. Sever combined immunodeficiency

28
Q

Question

A

D. Staphylococcus aureus

29
Q

Question

A

C. Neisseria meningiditis

30
Q

Question

A

D. Varicella zoster

31
Q

Question

32
Q

cell mediated 200

A

B. respiratory infections with encapsulated organisms

33
Q

Functions of the neutrophil

34
Q

Who has low or dysfunctional neutrophils?

35
Q

Common syndromes associated with neutropenia

36
Q

Things to remember considering neutropenia

37
Q

How do we protect neutropenic patients?

38
Q

Bottom-line of neutropenia

39
Q

Initial management of fever and neutropenia

40
Q

Question

41
Q

Cell-mediated immunity

42
Q

Who has dysfunctional cell-mediated immunity

43
Q

What are the common syndromes associated with impaired cell-mediated immunity?

44
Q

Common bacterial organisms associated with bacteria

A
  • Listeria moncytogenes
  • Nocardia spp.
45
Q

Common bacterial organisms associated with viruses

A
  • Herpes viruses
  • CMV
  • Hep B and C
46
Q

Common bacterial organisms associated with parasites

A

Toxoplasma gondii

47
Q

Common bacterial organisms associated with fungus

A
  • Histoplasma capsulatum
  • Coccidioides spp.
  • Cryptococcus spp.
  • Aspergillus spp,
  • Pneumocystis jirovecii
48
Q

Common bacterial organisms associated with mycobacteria

A
  • mycobacterium tuberculosis
  • nontuberculous mycobacterium
49
Q

How do we protect patients with dysfunctional cell-mediated immunity

50
Q

Question

51
Q

Timeline of Hematopoietic Stem Cell Transplantation

52
Q

Timeline of Hematopoietic Solid Organ Transplantation

Infectious Disease (82 decks)

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