Week 5 necrosis

Question 1

contrast karyolysis, pyknosis, and karyorrhexis

Answer 1

karyolysis: nucleus dissolves
pyknosis: nucelus condenses
karyorrhexis: nucleus fragments

Question 2

what are the cytoplasmic changes associated with necrosis?

Answer 2

cytoplasmic coagulation related to Ca influx(necrotic cells stain darker)

Question 3

what type of necrosis is described as “tomb stones” cells that maintain shape, with contraction bands, an abundance of neutrophils, and often seen in ischemia?

Answer 3

coagulative necrosis. do you know what this looks like on a slide? (heart, kidney)

Question 4

what type of necrosis is often seen in abscessed tissue and is decribed as being filled with cell debris, have aggregates of bacteria?

Answer 4

liquefactive necrosis (brain, abscess)

Question 5

what type of necrosis is described as looking like cottage cheese and has round “cookie-like” granulomas when stained?

Answer 5

caseous necrosis (lungs)

Question 6

what type of necrosis is described as soap bubbles with yellowing tissue due to calcium deposits?

Answer 6

fat necrosis (pancreas, breast)

Question 7

which necrosis types are associated with accute inflammation? chronic?

Answer 7

acute: coagulative, liquefactive
chronic: caseous, fat

Question 8

during the inflammatory response, which cells arrive first? which cells are there after prolonged necrosis?

Answer 8

first: neutrophils
prolonged: macrophages