Week 5 - IBD Flashcards
what is inflammatory bowel disease
- autoimmune disease that commonly refers to 2 disorders of the GI tract
- characterized by inflammation and ulceration
what 2 disorders are included in IBD
- Ulcerative colitis (UC)
- crohn’s
what is UC
- chronic IBD characterized by inflammation and ulceration of the rectum and colon
describe the progression of UC
- begins in the rectum and spreads proximally along the colon
what does inflammation in UC involve
- mucosa
- submucosa
describe the trajectory of UC
- involves periods of remissions and exacerbations
list symptoms of UC (5)
- bloody diarrhea
- abdominal pain
- urgent frequent need to defecate
- loss of weight, fluid, and electrolytes (d/t diarrhea and decreased mucosal SA for absorption)
- if mod or severe, systemic manifestations (ex. fever, malaise)
complications of UC are classified into which categories
- intestinal
2. extraintestinal
what are intestinal complications of UC (5)
- hemorrhage
- perforation –> peritonitis
- toxic megacolon
- colonic dilation
- colorectal Ca
what is toxic megacolon
- when the large intestine dilates due to the overwhelming inflammation
- the large intestine is unable to function properly and becomes paralyzed
- and can eventually can rupture.
- extensive dilation and paralysis of the colon
what is perforation in UC often associated with (2)
- toxic megacolon
- may also occur alone
what increases the risk of colorectal Ca in UC
- if they have had it for more than 10 years
what implication does the risk of colorectal ca have in a pt with UC
- pt should be regularly screened w colonoscopy
what is crohn’s disease
- chronic IBD of unknown origina
what part of the GI system does crohn’s impact
- can affect any part of the GI tract, from mouth to anus
crohn’s disease is characterized by.. (2)
- inflammation of segments of the GI tract = skip lesions
- inflammation of all layers of bowel wall
what are symptoms of crohn’s disease (7)
- non-bloody diarrhea**
- fatigue
- abdominal pain **
- weight loss
- fever
- abdominal cramping/tenderness
- abdominal distension
describe the onset of crohns
- pt experiences periods of remission & exacerbation
as crohn’s progresses, what does the pt experience (6)
- weight loss
- malnutrition
- dehydration
- electrolyte imbalances
- anemia
- pain around right lower quad and umbilicus
what are complications of crohn’s (5)
- stricture & obstruction
- fistulas
- perforation –> peritonitis
- intra-abdominal abcess
- malabsorption
what causes stricture and obstruction in crohn’s
- scar tissue
what do fistulas in crohn’s cause
- may communicate w lops of bowel, vagina, or urinary tract = feces in urine = UTi