Week 4 - Endocarditis Flashcards
what is infective endocarditis
- infection of the heart valves and/or the endocardial surface of the heart with formation of vegetations
what is infective endocarditis most commonly caused by
- bacteria –> staph and strep
what are other possible causes of infective endocarditis (2)
- fungi
- viruses
what are predisposing factors for infective endocarditis (4)
- prior endocarditis
- conditions that damage the valves
- IV drug use
- hospital acquired bacteremia (ex. dialysis, CVAD)
what are the “vegetations” seen in infective endocarditis
- primary lesions of IE
- consist of fibrin, leukocytes, patelets, and bacteria that adhere to the valves and endocardium
IE occurs when…
- blood flow turbelence within the heart allows the causative organisms to infect previously damaged valves or other endothelial surfaces and cause vegetations
what is a potential complication that can arise due to the vegetations in IE
- fragmentation and migration of the vegetations into the circulation causing embolization
emboli arising from a left sided heart vegetation will cause? (2)
- organ embolization
- vascular embolization
what organs can be affected by vegetations in the left side of the heart (3)
- kidney
- spleen
- brain
what can vascular embolization cause (5)
- limb infarction
- splinter hemorrages
- petichia
- janeaway’s lesions
- roth’s spots
- oslers nodes
where might you see petechiae from vascular embolization (4)
- feet
- ankles
- lips
- buccal mucosa
what are splinter hemorrhages
- black streaks in nail beds
what are roth’s spots
- lesions on the retina
what are janeaway lesions
- flat, painless red spots on the palm of the palm or soles of feet
what are osler nodes
- red/purple, painful, pea sized lesions on fingers or toes