Week 1 - Adrenal Disorders Flashcards
what are the 3 main classifications of adrenal cortex hormones (corticosteroids)
- glucocorticoids (cortisol)
- androgens
- mineralocorticoids (aldo)
what is the main fnxn of glucocorticoids (3)
- regulate metabolism
- increase glucose
- critical in stress response
what is the main fnxn of mineralocorticoids (aldo) (2)
- retains Na
- releases K
- helps regulate BP
what is the main fnxn of androgens
- contribute to growth and development in both genders
- sexual desire & satisfaction in women
what are the two main disorders associated with the adrenal cortex
- cushing’s
- addison’s
what is cushing’s syndrome
- conditions caused by too excess lvls of corticosteroids (especially glucocorticoids)
what can cause cushing’s syndrome (4)
- iatrogenic admin of prednisone
- tumour of the adrenal cortex
- other malignant growth that causes excess ACTH production (ex. lungs)
- tumour of the pituitary gland
what is cushing’s DISEASE
- when you have excess cortisol due to a tumour of the pituitary gland which then causes too much ACTH
what effect does cushing’s have on body composition (5)
causes:
- weight gain
- “moon face”
- “buffalo hump”
- trunkal obesity
- thin extremities & muscle wasting
what effect does cushing’s have on the skin and hair (5)
causes:
- thin and fragile skin
- purple striae
- bruises and petchiae
- acne
- excessive body and facial hair
what effect does cushing’s have on fluids & electrolytes and glucose (4)
- low K+
- high Na+
- water retention = increased BP
- hyperglycemia
what effect does cushing’s have on sexual characteristics (3)
in women:
- amennorhea
- hirsutism (start to have male characteristics)
in men:
- gynecomastia (development of breasts)
what effect does cushing’s have on bone’s
- can cause osteoporosis
how does cushing’s impact the immune system (2)
- causes increased suscpetibility to infection
- delayed wound healing
what effect does cushing’s have on personality and mood (3)
- causes personality changes
- depression
- CNS irritability
how can cushing’s syndrome be diagnosed (3)
- 24-hour cortisol urine sample
- blood & urine for cortisol lvls
- CT or MRI for tumours
what is the treatment goal for cushings
- normalize hormone secretion
how is treatment of cushings chosen
- based off cause
if the underlying cause of cushings is a pituiatry tumour or adrenal gland, what is the treatment (3)
- surgery
- radiation
- drug therapy to remove tumour or inhibit adrenal function
if the underlying cause of cushings is prolonged corticosteroid use, what is the treatment (3)
- tapered discontinuation of corticosteroid therapy
- reduction of dosage
- conversion to alternate day therapy
why is it important to never dc corticosteroids abruptly?
- may cause life-threatening adrenal insufficiency
why is it important to offer emotional support to a pt with cushings? how can we offer this?
- changes in appearance/emtional behavior are distressing
- reassure that once cortisol levels are restored they will look and feel normal again
what should you monitor for post-op (after tumour removal) for a pt with cushings (3)
- electrolyte balance
- hemorrhage
- corticosteroid lvl
- S&S of addison’s
why is it important to monitor electrolytes post-op for a pt with cushings
- surgery can cause fluctuating hormones = unstable electrolytes