Week 4 - Peripheral Artery Disease, Acute Arterial Ischemia, Amputation Flashcards
what is peripheral artery disease
- thickening of the arterial walls that leads to progressive narrowing of the artery lumen
what is the leading cause of PAD
- atherosclerosis
where does PAD occur
- in extremities
what are the most significant risk factors for PAD (5)
- tobacco use
- hyperlipidemia
- elevated CRP
- DM
- HTN
what are other risk factors for PAD? (7)
- FHx
- hypertriglyceridemia
- hyperuricemia
- increasing age
- obesity
- stress
- sedentary lifestyle
what is the classic sign of PAD
- intermittent claudification
what is intermittent claudification
- an ischemic muscle ache or pain that is precipitated by a consistent lvl of exercise
how long does intermittent claudification last
- 10 min or less
- is reproducible
what causes intermittent claudification
- accumulation of end products of anaerobic cellular metabolism ex. lactic acid
what causes intermittent claudification to go away
- once the person stops exercising and the metabolites are cleared
PAD of the aortoiliac arteries produces pain where? (2)
- buttocks
- thinghs
PAD of the femoral or popliteal artery produces pain where? (1)
- calf
what is the best treatment for intermittent claudification (2)
- walking for 30-60 min/day and 3-5 times/week
- meds
what 2 meds are used for intermittent claudification
- pentoxifylline (trental)
- levocarnatine (cranitine)
what are the signs of PAD (9)
- parasthesia of toes or feet
- thin, shiny, hairless and taut skin
- cool skin
- diminished or absent pulses
- intermittent claudification
- neuropathies
- brittle nails
- prolonged cap refill
- non healing ulcers & gangrene (later)
what color does the skin turn in PAD and what impacts this (2)
- pallor if elevated
- red when dependent
how does pain in PAD change w time
- eventually will occur at rest too
what causes rest pain
- when there is insufficient blood flow to meet basic metabolic needs of distal tissues
when is rest pain more promininent during PAD? why?
- at night
- bc cardiac output drops and limbs are at lvl of heart
what position can help relieve pain in PAD (2)
- dangling legs over side of bed
- sleeping in chair
what are signs of critical limb ischemia (3)
- chronic rest pain
- gangrene
- ulceration
what are complications of PAD (6)
- delayed healing
- wound infection
- tissue necrosis
- nonhealing arterial ulcers **
- gangrene **
- amputation
what do arterial ulcers look like (2)
- round, punched out looking
- minimal drainage
where do arterial ulcers most commonly occur (4)
over bony prominences
- toes
- feet
- lower leg
- lateral malleolus
describe what you would find on assessment of an arterial ulcer (3)
- cool to touch
- decreased/absent pedal pulses
- cap refill >3 sec
what can be used to diagnose PAD (5)
- doppler US
- segmental BP at thigh, below knee, and at ankle
- ankle brachial index
- angiography
- magnetic resonance angiography
when is a doppler US useful
- if palpation of a peripheral pulse is difficult bc of severe PAD, it can determine the degree of blood flow
what is the ankle brachial index (2)
- a comparative test of BP of the arm vs ankle to monitor blood flow
- uses a handheld doppler
what are the categories of care for PAD (8)
- risk factor modification
- drug therapy
- exercise therapy
- nutritional therapy
- care of the leg with critical limb ischemia
- complementary and alternative therapy
- interventional radiology catheter-based procedures
- surgery
what risk factor modifications are imp to reduce CVD risk factors (6)
- healthy body weight
- regular physical activity
- smoking cessation
- optimal BP control
- optimal glycemic control
- lower cholestrol (thru diet & meds)
what diabetes increase the risk of for pts with PAD
- amputation
what type of meds are used for treatment of PAD (5)
- antiplt
- pentoxifylline (Trental)
- cilostazol (pletal)
- ACE-I
- alternative med therapy
why are antiplts imp for treatment of PAD (2)
- reduce risks of CVD events
- and reduce risk of death in PAD pts
what 2 antiplt meds are recommended for treatment of PAD
- aspirin OR
- clopidogrel (Plavix)
*combo therapy of the 2 are not recommended)
what are not recommended for prevention of CVD events in pts with PAD
- anticoagulants
what benefit do ACE-I have in treatment for PAD
- decreased morbidity & mortality risks
what 3 drugs are used to treatment intermittent claudification
- pentoxifylline (trental)
- cilostazol (pletal)
- levocarnatine (carnitor)
what does cilostazol do? (3)
promotes effects of prostaglandin :
- increased vasodilation
- inhibits platelet aggregation
what does trental do>
- increases RBC flexibility
- decreases blood viscosity
what are some examples of alternative med therapy that have been investigated in the treatment of intermittent claudifcation (4)
- vitamins
- minerals
- dietary
- herbal supplements
what should pts do prior to using alternative med therapy
- consult with their HCP prior to taking any dietary or herbal supplements if on antiplt, NSAIDs, or anticoags d/t interactions and bleeding risks
describe exercise therapy for a pt with PAD (5)
- walking
- supervised rehab PAD progrsm is best
- home exercise programs
- at home, strive for 30-40 min/day 3-5x/week
- the pt should walk to the point of discomfort, stop & rest, and then resume walking until it recurs
what nutritional therapy should be implemented for a pt with PAD (6)
- adjust their dietary intake so at a healthy weight
- high fruits & veggies
- high whole grains
- low cholestrol
- low sat fat
- low sat