Week 3 - Mon - Trafficking of Membrane Proteins Flashcards
vesicles
membrane enclosed sacks
membrane enclosed sacks
vesicles
ER
endoplasmic reticulum
ribosomes attach to a part of the cell membrane called the ________________
rough endoplasmic reticulum
the smooth endoplasmic reticulum lacks_________
ribosomes
cytosol
contains many metabolic pathways , protein synthesis, the cytoskeleton
nucleus
contains main genome, DNA + RNA synthesis
ER (endoplasmic reticulum)
synthesis of most lipids, synthesis of proteins for distribution to many organelles and to the plasma membrane
golgi apparatus
modification, sorting, and packaging f proteins and lipis for either secretion of delivery to another organelle
lysosomes
intracellular degradation
endosomes
sorting of endocytosed material
mitochondria
ATP synthesis by oxidative phosphorylation
chloroplasts
ATP synthesis and carbon fixation by photosynthesis
peroxisomes
oxidation of toxic molecules
how are organelles held in place?
attachment to cytoskeleton / microtubules
how do mitochondria, chloroplasts, peroxisomes and the nucleus get their required proteins?
directly through the cytoplasm
how do the lysosomes, endosomes, golgi apparatus, and inner nuclear membrane get their proteins?
indirectly through the ER –» golgi –»distributed
the synthesis of virtually all proteins begins on ______ in the ______
ribosomes, cytosol
a sorting signal is______
an amino acid sequences that directs the protein to the organelle in which it is required
3 methods of protein transport
nuclear pore, protein translocators, transport vesicles
proteins must _______ to work through the _______ and move from the cytosol into the ER
unfold , protein translocator
the signal sequence is typically between ___ and ____ amino acids long, and is usually______ from the protein once finished
15-60, removed
_______ encloses the nuclear DNA and defines the nuclear compartment
nuclear envelope
