MidTerm - Final push Flashcards

1
Q

can phosphorylation inhibit?

A

yes

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2
Q

a molecule that resembles a substrate, and fills active/binding pocket without catalyzing a reaction is a __________

A

competitive inhibitor

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3
Q

malonate _______ succinate hydrogenase by filling its active site and preventing the conversion of succinate to fumarate

A

inhibits

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4
Q

where does phospholipid synthesis take place?

A

endoplasmic reticulum

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5
Q

covalent bond

A

two atoms share electrons (valence electrons)

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6
Q

AC - ref GPCR

A

adenylyl cyclase

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7
Q

providing ______ can be helpful for patients with methanol poisoning

A

ethanol

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8
Q

does catalysis change delta G

A

no

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9
Q

what’s an enzyme?

A

a highly specific catalyst

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10
Q

where does glycolysis take place?

A

cytoplasm

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11
Q

AP ref - RTK

A

adaptor protein

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12
Q

APC (ref cell cycle )

A

anaphase promoting complex

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13
Q

the lipid present in Wnt does what?

A

helps bind it to it’s origination cell

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14
Q

a kinase _____ a substrate

A

phosphorylates

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15
Q

nucleating element of microtubules

A

G turc

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16
Q

catabolism

A

glucose –> glycolysis or citric acid cycle

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17
Q

what motor proteins make sperm swim?

A

dynein motor proteins

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18
Q

is ATP stored?

A

no! it’s continuously generated

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19
Q

RAP ref- rtk

A

ras activating protein

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20
Q

are carbons oxidized to C02 in the CAC

A

yes

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21
Q

can phosphorylation activate?

A

yes

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22
Q

3 activities powered by ATP hydrolysis

A

pumping/transport
movement/mechanical
biosynthetic

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23
Q

can the CAC occur in anaerobic conditions?

A

no, it indirectly requires O2

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24
Q

cation

A

-electrons

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25
Q

what role do microtubules play in mitosis?

A

chromosomal organization

26
Q

polar molecule

A

resulting from polar bonds, asymmetric electron sharing

27
Q

APC (ref - wnt)

A

adenomatous polyposis coli)

28
Q

what causes dynamic instability?

A

the GTP tubulin dimers hydrolyze into GDP, and lose stability

29
Q

the inhibition/degradation of securin leads to ______

A

anaphase

30
Q

motif/scheme of signaling pathways

A
  1. signal reception - on receptor, in or out2. relay mechanism - pathway/cascade3. downstream effects - on effector, what happens?
31
Q

microtubule polarity (micro/macro)

A

polar/polar

32
Q

kinesin purpose

A

motor protein, axonal transport etc.

33
Q

APC ubiquitinates both ______ and _______

A

M-Cyclin, Securin

34
Q

sperm are made of _______ exoskeletal component

A

microtubules

35
Q

if you remove an electron from hydrogen, you get…

A

a proton

36
Q

non-polar molecules are hydro_______

A

phobic

37
Q

are enzymes and substrates bound by covalent bonds?

A

NO!

38
Q

active transport

A

movement of molecules against the electrochemical gradient

39
Q

passive transport

A

movement of molecules down the electrochemical gradient

40
Q

channel protein

A

channel that facilitates transport without a major conformational change

41
Q

symport

A

two proteins moving through one

42
Q

opposite of channel protein

A

carrier or transporter protein

43
Q

is a uniport a channel or carrier?

A

can be both

44
Q

is a symport a channel or carrier?

A

carrier

45
Q

is a symport passive or active?

A

both, a symport will usually have one solute that’s moving down the electrochemical gradient, while another is moving up

46
Q

is an antiport passive or active?

A

both! An antiport will facilitate one molecule moving against the gradient, powered by one molecule moving down the gradiet

47
Q

is an antiport a channel or carrier

A

carrier

48
Q

Rab proteins

A

proteins on the cytoplasmic face of vesicle that provide the address code for interaction with correct target membrane

49
Q

Where is the V-snare?

A

on the vesicle

50
Q

where is the T- snare?

A

on the target membrane

51
Q

what docks to the Rab?

A

tethering proteins

52
Q

endocytosis

A

taking in of a vesicle

53
Q

exocytosis

A

exportation of vesicle

54
Q

dynamin

A

pinches off vesicle bud neck during exocytosis

55
Q

clathrin coat

A

coat of vesicle that buds off

56
Q

adaptin

A

barrier between clathrin coat and cargo receptor

57
Q

kinesin movement

A

huge conformational change, moves it’s back head forward/”forward step” / power stroke

58
Q

how does ATP affect myosin

A

it causes it to release

59
Q

M-Cyclin ________ MCdk

A

activates

60
Q

are the levels of MCdk in the cell variable

A

no

61
Q

are the levels of M-Cyclin in a cell variable

A

yes

62
Q

how does G protein stop the formation of cancer cells

A

G protein has inherent GTPAse activity. Can hydrolyze GTP–> GDP and become switched off, so it’s not constantly active.