Week 2 review

Question 1

Which antibody binds best with carbohydrates?

Answer 1

IgM because of pentameric structure and the 10 Antigen binding domains

Question 2

What are 2 antigenic determinants and their B/T cell receptor preference?

Answer 2

Sequential (TCR)

and Conformational (recognized by Ig)

Question 3

what is the antibody that is the first Ig to respond to bacteria/pathogen?

Answer 3

IgM

Question 4

What type of bonds populate the hinge region of the Ig?

Answer 4

disulfide bonds

Question 5

What region of the antibody binds the antigen?

Answer 5

Variable region

Question 6

What part of the antibody mediates the effector fx?

Answer 6

the Constant region (FcR binding, opsonophagocytosis, activation of C1q)

Question 7

how many antibodies can there be when you consider heavy and light chain combinations?

Answer 7

10
M, D, G, E, A
with a kappa or a gamma light chain

Question 8

how many antibodies can there be when you consider heavy and light chain combinations?

Answer 8

10
M, D, G, E, A
with a kappa or a gamma light chain

Question 9

What antibody is important for mucosal immunity?

Answer 9

IgA: GI, respiratory tract and lungs, milk, GU tract

Question 10

What is the difference between affinity and avidity?

Answer 10

affinity: behavior or a single Ab molecule at equilibrium (IgG>M)
avidity: cumulative binding activity/capacity of all recognition sites on an antibody (IgM>IgG)