Rheumatoid Arthritis

Question 1

What are 3 relevant labs performed for Rheumatoid Arthritis?

Answer 1

1) Rheumatoid Factor
2) Anti-cyclic citrullinated peptide (anti-CCP): ELISA test, rules in the disease
3) Antinuclear Antibody (ANA)

Question 2

What is the clinical manifestation of RA?

Answer 2

symmetric polyarticular synovitis
Morning stiffness for about 1 hour
Pain, fatigue, weight loss, fever
Systemic Disease

Question 3

What are some predisposing factors for developing RA?

Answer 3

Women 50-70

Family hx

Question 4

Where does RA present first?

Answer 4

PIPs

Question 5

What are the Non-specific markers of inflammation labs obtained to track RA progression?

Answer 5

Sed rate (disease activity/severity
CRP (determines amount of inflammation)

Question 6

What are three components of cartilage?

Answer 6

Type II collagen
Proteoglycans
Chondrocytes

Question 7

What are the components of joints?

Answer 7

Collagen

Synovium

Question 8

How are joints affected in osteoarthritis as opposed to RA?

Answer 8

unilateral joints or singular joints affected in OA

Question 9

What is the genetic predisposition for RA?

Answer 9

HLA-DRB3

Question 10

What are important cytokines involved in RA?

Answer 10

IFN gamma
TNF
IL-1
IL-17