Selective t cell deficiencies Flashcards
1
Q
What stage of T cell differentiation does selective T cell deficiencies affect?
A
Mutations in genes involved in differentiation of naive t cells into effector cell population
2
Q
What underlying chemical deficiencies explain Th1 deficiencies?
A
IFN-gamma R1
IL12BR1 (produced by dendrites and macs for Th1 differentiation)
IL-12 deficiency
3
Q
What underlying chemical deficiency explains a Th17 deficiency?
A
IL-17
4
Q
What sort of infections are you predisposed to if you have a Th1 deficiency?
A
Atypical Mycobacterial infections
5
Q
What sort of infections are you predisposed to developing if you have a Th17 deficiency?
A
Chronic Candida albicans (thrush) and S Aureas infections
