Tolerance and Immunity

Question 1

6 Polymorphic genes related to Susceptibility to generate B cell tolerance

Answer 1

HLA alleles
PTPN22
NOD-2
CO25
IL-23
CTLA-4

Question 2

Environment predisposing genetic susceptibility

Answer 2

Infection
Tissue Damage
Sex (women)

Question 3

Where does central tolerance take place?

Answer 3

primary lymphoid organs: spleen and bone marrow

Question 4

peripheral tolerance occurs where?

Answer 4

peripheral lymphoid organs and non-lymphoid tissues

Question 5

Auoimmune diseases and their respective Coombs hypersensitivity designation

Answer 5

-Graves: Type II
Anti-TSH receptor antibodies that acts as antagonist
(–> thyroid hyperplasia and hyperthyroidism)

-Goodpastures
Type II; Anti-collagenous domains of Type IV collagen of glomerular basement membrane

-Multiple Sclerosis: Type IV

-Systemic Lupus Erythematosus
Type III

-Type 1 Diabetes