Chediak-Hiagashi Syndrome Flashcards
1
Q
Chediak-Higashi affects which branch of the immune system?
A
The Innate Immunity
2
Q
What defects are associated with Chediak-Higashi syndrome?
A
Neutrophils and Macrophages have defective vesicle formation and trafficking.
Natural Killer cells and CTLs can’t release granules
3
Q
What is the presentation of Chediak-Higashi syndrome?
A
Frequent and severe bacterial infections, usually pyogenic, because lysosomes can’t be produced. Particular types of albinism (partial oculoalbninism)
