Week 16 / GI system 2 Flashcards
Q: What shape is the stomach, and what is its most notable feature?
A: The stomach is a J-shaped sac-like chamber and is the most distensible part of the gastrointestinal tract.
Q: What are the main functions of the stomach?
[6]
Stores ingested food
Secretes gastric juice (acid, mucus, intrinsic factor, digestive enzymes)
Mixes food with gastric juice
Initiates digestion of proteins and fats
Kills bacteria
Moves food (chyme) at a controlled and steady rate into the duodenum.
Q: What components make up the gastric juice secreted by the stomach? [4]
A: Gastric juice consists of:
Hydrochloric acid (HCl)
Mucus
Intrinsic factor
Digestive enzymes (e.g., pepsin and lipase)
Q: What role does gastric juice play in digestion? [3]
Initiate digestion of proteins and fats
Kill bacteria through the acidic environment created by HCl
Facilitate enzyme activity, especially pepsin, in protein breakdown.
Q: How does the stomach move food (chyme) into the duodenum?
the pyloric sphincter.
Q: What is the function of the fundus in the stomach?
A: The fundus is the upper part of the stomach, which stores food and gas. It is involved in gastric juice secretion and serves as a reservoir for food before it moves to the body.
Q: What is the role of the esophagus?
A: The esophagus carries food from the mouth to the stomach
What is the role of the lower esophageal sphincter in relation to the stomach?
the lower esophageal sphincter (LES) controls the opening between the esophagus and the stomach to prevent stomach contents from refluxing back into the esophagus.
Q: What does the body of the stomach secrete? [3]
Mucus (protective lining)
Pepsinogen (inactive enzyme precursor)
Hydrochloric acid (HCl) (for digestion and sterilization)
Q: What is the role of the duodenum in the stomach’s function?
A: The duodenum is the first part of the small intestine, and it receives chyme from the stomach through the pyloric sphincter. It is the site where further digestion of nutrients occurs and bile from the liver and enzymes from the pancreas are added.
Q: What is the function of the pyloric sphincter?
A: The pyloric sphincter regulates the passage of chyme from the stomach into the duodenum, controlling the rate at which food moves from the stomach to the small intestine.
Q: What does the antrum of the stomach secrete? [3]
Mucus (for protection)
Pepsinogen (to aid in protein digestion)
Gastrin (a hormone that stimulates gastric acid secretion and motility)
What are gastric folds?
What is the function of gastric mucosal folds in the stomach?
A: Gastric mucosal folds are the folds in the stomach lining.
allow the stomach to expand when filled with food. They also help to increase the surface area for digestion and absorption.
What are gastric pits?
what is their role?
A: Gastric pits are small depressions in the stomach lining that lead to the gastric glands
They house specialized cells that secrete gastric juices, such as mucus, hydrochloric acid (HCl), and digestive enzymes.
Q: What do mucous cells in the gastric mucosa secrete?
Whats the function of whats secreted ?
Mucous cells secrete mucus,
which forms a protective barrier that shields the stomach lining from the corrosive effects of gastric acid and digestive enzymes.
Q: What are the components of gastric glands and what do they secrete?
A: Gastric glands are located at the base of gastric pits and contain several types of cells:
Parietal cells – Secrete hydrochloric acid (HCl) and intrinsic factor
Chief cells – Secrete pepsinogen (the inactive form of the enzyme pepsin)
Mucous cells – Secrete mucus to protect the stomach lining.
Q: What is the role of parietal cells in the stomach?
A: Parietal cells secrete hydrochloric acid (HCl), which aids in food digestion by lowering the stomach pH, and intrinsic factor, which is necessary for vitamin B12 absorption in the small intestine.
Q: What do chief cells secrete in the stomach?
A: Chief cells secrete pepsinogen, the inactive form of the enzyme pepsin. Pepsinogen is activated by HCl into pepsin, which then begins protein digestion in the stomach.
Q: What is the function of the submucosa in the stomach?
A: The submucosa is a layer of connective tissue that supports the mucosa. It contains blood vessels, lymphatics, and nerve fibers, and helps provide nutrients to the stomach lining and regulates digestive functions.
Q: What is the source of hydrochloric acid (HCl) in the stomach and its function?
A: Hydrochloric acid (HCl) is secreted by parietal cells in the stomach. Its function is to sterilize the ingested meal by killing pathogens and assist in the hydrolysis of food, especially proteins.
Q: What is the source of intrinsic factor in the stomach ?
What is the function?
A: Intrinsic factor is secreted by parietal cells.
Its function is to aid in the absorption of vitamin B12 in the small intestine.
What is the source of pepsinogen in the stomach?
What is the function?
A: Pepsinogen is secreted by chief cells in the stomach.
It is an inactive precursor to pepsin, an enzyme that digests proteins once activated by acidic conditions in the stomach.
Q: What is the source of mucus and bicarbonate in the stomach?
What is the function?
A: Surface mucous cells secrete mucus and bicarbonate.
These products form a protective layer on the stomach lining, providing gastroprotection from the corrosive effects of gastric acid and digestive enzymes.
What are trefoil factors secreted by?
what is their function in the stomach?
Trefoil factors are secreted by surface mucous cells
play a role in gastroprotection, particularly in mucosal healing and repair.