Week 12 - NSAID

Question 1

Acetylsalicylic Acid (Aspirin) MOA

Answer 1

inhibits prostaglandin synthesis and has greater anti-inflammatory activity than the NSAIDs. Salicylates lower body temperature through their effect on the hypothalamic thermostat and vasodilation of peripheral vessels, thus enhancing dissipation of heat

Question 2

Acetylsalicylic Acid (Aspirin) indication

Answer 2

rheumatic fever, RA, transient ischemic attacks (TIAs), coronary artery disease, and deep vein thrombosis, post MI

Question 3

Acetylsalicylic Acid (Aspirin) SE

Answer 3

-Reye’s syndrome in children/adolescents.
-GI irritation and bleeding (do not take with alcohol or GI irritation).
-Ototoxic, temporary hearing loss and tinnitus, STOP IF OCCURS.
-Prolongs bleeding time

Question 4

Celecoxib MOA

Answer 4

COX - 2 inhibitor

Question 5

What is Cox-2

Answer 5

an inducible enzyme that is synthesized mainly in response to pain and inflammation, inhibits this action

Question 6

Celecoxib indication

Answer 6

Osteoarthritis
RA

Question 7

Celecoxib SE

Answer 7

Black box warning for CV disease

Question 8

Non specific Cox inhibitors (I MAN DIK)

Answer 8

● Indomethacin (Indocin)
● Meloxicam (Mobic)
● Aspirin (Acetylsalicylic Acid)
● Naproxen (Aleve)
● Diclofenac (Voltaren)
● Ibuprofen (Advil)
● Ketorolac (Toradol)

Question 9

Black box warning for NSAID’s

Answer 9

GI bleed

Question 10

Use NSAID’s cautiously for patients with…

Answer 10

Renal impairment