Week 11 - Acid Neutralizing Agents

Question 1

The site of action of the antacids is ___________ and they have _____________ absorption

Answer 1

GI tract, minimal

Question 2

Chronic use of antacids may ________ their absorption

Answer 2

increase

Question 3

What are the commonly used metallic cations present in antacids?

Answer 3

• Aluminum
• Magnesium
• Calcium

combined with a with a basic anion such as hydroxide, or carbonate

Question 4

In addition to neutralizing gastric acidity, antacids may also _________ lower esophageal sphincter tone

Answer 4

Increase

Increased tone = less acid escaping into the esophagus

Question 5

Administration of antacids _________ meals leads to the longest reduction in gastric acidity

Answer 5

After

Question 6

All antacids are contraindicated in the presence of ____________

Answer 6

severe abdominal pain, especially with fever

Question 7

Calcium based antacids are contraindicated in the presence of _______

Answer 7

• hypercalcemia
• renal calculi

Question 8

Many antacids have a high _________ content making them contraindicated in patients with what diseases?

Answer 8

Sodium
* hypertension
* congestive heart failure
* renal failure

Question 9

Renal failure is a contraindication for antacids containing ________

Answer 9

Aluminum and Magnesium

Question 10

________ based antacids cause constipation and __________ based antacids cause diarrhea

Answer 10

• calcium, aluminum
• magnesium

(magnezuma’s revenge…)

Question 11

All antacids may interact with weakly acidic or basic drugs - how can this be minimized?

Answer 11

administering the interacting drug at least 2 hours before the antacid