Week 10 - SNRIs

Question 1

What is the MOA for SNRIs?

Answer 1

Affects serotonin and norepinephrine transporters in synaptic cleft, blocks it from returning remaining serotonin back to presynaptic cell increases binding to postsynaptic membrane.

Question 2

True or False?

SNRIs are first line in more sluggish types of depression?

Answer 2

True, due to more activation that SSRIs

Question 3

What are the indications for use of SNRIs?

Answer 3

Depression
PTSD
GAD
Neuropathic pain
Overactive bladder
Fibromyalgia

Question 4

The SNRI ____________ when used concurrently with a triptan will result in ______________?

Answer 4

Milnacipran
Serotonin syndrome

Question 5

If administered along with norepinephrine and epinephrine, ____________ can cause paroxysmal hypertension

Answer 5

Milnacipran

Question 6

What is the only SNRI indicated for fibromyalgia?

Is it its only use?

Answer 6

Milnacipran
Yes

Question 7

Duloxetine should not be used in patients with which disorder?

Answer 7

Liver disorders

Question 8

What four drugs on the drug list do we have to know for SNRIs?

Answer 8

Venlafaxine
Desvenlafaxine
Duloxetine
Milnacipran