Week 11 - Cytoprotective Agents Flashcards
1
Q
What medications are classified as cytoprotective?
A
- Sucralfate
- Bismuth Subsalicylate
2
Q
What is the MOA of sucralfate?
A
- selective bind to necrotic ulcer tissue (acts as a barrier)
- stimulates endogenous prostaglandin synthesis (central to formation/maintenance of protective mucosa)
3
Q
True or false:
Sucralfate has acid-neutralizing activity
A
False
4
Q
Sucralfate has ________ specific precautions or contraindications.
A
no - it’s action is topical and is essentially not absorbed
5
Q
What is the most frequent complaint when taking sucralfate?
A
Constipation
6
Q
Sucralfate may _______ the absorption of several drugs when given concurrently
A
decrease
7
Q
To minimize the effect that sucralfate has on the absorption of other drugs it should be administered _________
A
at least 2 hours after the interacting drug
8
Q
Ingestion of sucralfate and antacids should be separated by ______
A
at least 2 hours
