Week 12 - Muscle Relaxants and Antispasmodics Flashcards
Baclofen MOA
works on the gamma-aminobutyric acid (GABA) receptors in the spinal cord, reducing nerve signals that cause muscle spasms and spasticity
Baclofen indication
muscle spasticity associated with conditions like multiple sclerosis, spinal cord injuries, and cerebral palsy.
Baclofen SE
drowsiness, dizziness, weakness, nausea. ** may cause neuropsychiatric effects, including confusion, headache, insomnia, and seizures.
Abruptly stopping can lead to withdrawal symptoms, so taper slowly
Carisoprodol MOA
Muscle relaxant-likely works by altering interneuronal activity in the descending reticular formation and spinal cord, resulting in muscle relaxation.
Carisoprodol indication
relieve acute, painful musculoskeletal conditions and discomfort associated with muscle injuries and spasms.
Carisoprodol SE
drowsiness, dizziness, headache, and dry mouth.
** on Beer’s list for older adults
It has the potential for abuse and may cause dependence if used improperly.
Cyclobenzaprine MOA
acts on the central nervous system by inhibiting motor neuron activity, leading to reduced muscle spasms.
Cyclobenzaprine indication
short-term treatment for muscle spasms and pain associated with acute musculoskeletal conditions.
Cyclobenzaprine SE
dry mouth, dizziness, drowsiness, and blurred vision. ** on Beer’s list for older adults.
Anticholinergic effects, use cautiously in patients with urinary retention, angle-closure glaucoma, or increased intraocular pressure.
Hepatotoxic.
Cyclobenzaprine is contraindicated in patients with
** hyperthyroidism, myocardial infarction or who have heart failure, dysrhythmias, or conduction disturbances.
Methocarbamol drug class
Muscle relaxant
Methocarbamol indication
acute musculoskeletal conditions and pain associated with muscle injuries and spasms. IV administration can be used to treat tetanus.
Tizanidine MOA
works by activating alpha-2 adrenergic receptors, leading to reduced nerve signals that cause muscle spasticity.
Tizanidine indication
treat muscle spasticity associated with conditions like multiple sclerosis, spinal cord injuries, and other neurological disorders. Only for use when spasticity is affecting daily life
Tizanidine SE
*** remember, it is A2 agonist.
It can cause low blood pressure, so patients should be cautious when standing up. Hepatotoxic.
Do not abruptly stop, can cause hypertension, tachycardia, and hypertonia.
