Week 10 - MAOIs

Question 1

True or False

MAOIs are infrequently used because safer drugs are available.

Answer 1

True

Question 2

A washout period should occur if switching to an SSRI or NNSRI from an MAOI for ___________ weeks.

Answer 2

Two to five

Question 3

What is the MOA of MAOIs?

Answer 3

Irreversibly inactivate enzymes that metabolize norepinephrine, serotonin, and dopamine.

Prevents breakdown of tyramine.

Question 4

What foods should patients avoid when taking MAOIs?

Answer 4

Aged/cured meats and foods, smoked meats, pickled or fermented foods.

Question 5

The relief of symptoms with MAOIs as compared to tricyclic antidepressants and SSRIs is ___________ ?

Answer 5

Shorter, around fourteen days.

Question 6

What are contraindications to MAOIs?

Answer 6

Liver/kidney disease
CHF
Arteriosclerotic disease
Old age

Question 7

What are the most common side effects of MAOIs?

Answer 7

Anticholinergic effects including…

Dizziness
HA
Insomnia
Restlessness
Hypotension

Question 8

Periodic monitoring of __________ function should be performed with MAOIs.

Answer 8

Liver

Question 9

Selegiline is an MAOI with an adjunct treatment for _______________ ?

Answer 9

Parkinson’s disease

Question 10

Which MAOI should not be taken currently with meperidine?

Answer 10

Selegiline

Question 11

Because MAOIs inhibit the metabolism of norepinephrine, _______________ can occur when given with drugs/foods that raise blood pressure.

Answer 11

Hypertensive crisis