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Block 6 > WBC and associated changes > Flashcards

WBC and associated changes Flashcards

1
Q

absolute WBC count

A

WBC * % cell type

quantitative measure

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2
Q

relative WBC count

A

% cell type

depends on number of other line

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3
Q

granulocyte

A

neutrophil
eosinophil
basophil

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4
Q

myeloperoxidase

A

neutrophil primary granule

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5
Q

alkaline phosphatase

A

neutrophil secondary granule

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6
Q

leukemoid reaction

A

elevated WBC with immature cells
20-50k neutrophils
indicates stress
Dohle bodies present

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7
Q

leukoerythroblastic blood picture

A

leukemoid WBC + elevated RBC

reactive, neoplastic, marrow disorder

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8
Q

neutrophilia

A 
elevated neutrophils
bacterial infection
tissue necrosis
physiologic stress
hematologic disorders
drug reaction
metabolic
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9
Q

normal WBC count

A

5-10k

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10
Q

neutropenia

A

decreased neutrophils

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11
Q

causes of decreased marrow production of neutrophils

A 
toxicity
aplastic anemia
myelophthisis
nutritional deficiency
collagen diseases
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12
Q

causes of increased destruction/use of neutrophils

A

splenic sequestration
viral infections
immune mediated
prolonged inflammation

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13
Q

drugs associated with neutropenia

A

antibiotics

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14
Q

monocyte main function

A

phagocytosis

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15
Q

main cause of monocytosis

A

neutropenia
chronic inflammation
malignancy

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16
Q

eosinophil function

A

limit chronic inflammatory responses

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17
Q

eosinophil graunles

A

peroxidase

acid phosphatase

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18
Q

eosinophil membrane receptors

A

IgG

complement

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19
Q

causes of eosinophilia

A

parasite infection
allergy
drug reactions

20
Q

chronic hypereosinophilic syndrome

A

persistent elevation in eosinophils
rare
needs to be treated early

21
Q

basophil granules

A

histamine

heparin-like mucopolysaccharides

22
Q

basophil membrane receptors

A

IgE

23
Q

basophil function

A

hypersensitivity reactions

24
Q

basophilia cause

A

myeloproliferative disorders- CML

hypersensitivity reactions

25
Q

which is more b or t cells

A

T cells

26
Q

which lives longer b or t cells

A

T cells

27
Q

b cell function

A

humoral immunity

antibody production

28
Q

T cell function

A

cellular immunity

b cell inducer

29
Q

mechanical interference with lymphocytes

A

thoracic duct obstruction

intestinal lymphatics with poor absorption

30
Q

layers of the folicle

A

germinal center- CD10+
mantle- CD5+
marginal zone- CD5/10-

31
Q

precursor B lymphoblasts

A

precursor for entire b cell lineage

TdT

32
Q

naive mature B cell

A

circulating in blood
primary follicle and mantle zone
sIg- M D
have not found antigen

33
Q

germinal center blasts- b cells

A

found antigen, returned to germinal center secondary follicle
CD10, BCL6 +
BCL2 and sIg negative
IgM switch to IgG or IgA

34
Q

CD10+

A

germinal center lymphocyte

found the antigen pair

35
Q

BCL2

A

anti apoptosis

in all cells except centroblasts

36
Q

germinal center centrocytes

A

secondary germinal center resting cells
sIg
BCL2 +
IgM or IgA

37
Q

plasma cells

A

return to bone marrow
CD79a, CD138 +
BCL6, sIg, CD20, CD5, CD10 -
produces antibodies

38
Q

memory B cells

A

go back to lymphoid organ origin
sIg, CD20, BCL2 +
BCL6, CD5, CD10 -
IgM

39
Q

lymphocytosis of acute infections

A

infectious mono (EBV)
pertussis
other viruses

40
Q

lymphocytosis

A

chronic infection
thyrotoxicosis
drug sensitivity
hematologic malignancy

41
Q

lymphopenia

A

immunodeficiency syndromes
lymphocyte destruction
mechanical loss
neoplasms

42
Q

monocyte granules

A

lysozyme

43
Q

myeloid maturation

A

myeloblast
promyelocyte
myelocyte
metamyelocyte

44
Q

CD20

A

memory b cell marker

45
Q

CD138, CD79a

A

plasma cell marker

Block 6 (24 decks)

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