Bipolar Drugs Flashcards
1
Q
3 classes of treatment
A
litium
anticonvulsants
atypical antipsychotics
2
Q
first line bipolar
A
lithium
3
Q
MOA lithium
A
not known
increases hippocampal and amygdala volume
4
Q
therapeutic range Li
A
0.5-1.0
5
Q
effects of >1.5 Li
A
tremor
nausea
diarrhea
6
Q
effects of >2 Li
A
neurotoxicity
delirum
7
Q
effects > 3 Li
A
fatal
8
Q
Li clearance
A
renal
affected by diuretics and anti-inflammatory drugs
9
Q
mild side effects Li
A
headache fatigue confusion thirst polyuria weakness
10
Q
severe side effects Li
A
monoclonal jerks seizures impaired consciousness coma death
11
Q
cardiac effects of Li
A
EKG irregularities
cardiac arrest
12
Q
Li contraindications
A
pregnant
breastfeeding
13
Q
effects of Li on fetus/baby
A
floppy baby syndrome
fetal goiter
Epstein’s abnormality
arrhythmias
14
Q
second line bipolar drugs
A
anticonvulsants
15
Q
carbamazepine
A
first gen anticonvulsant
stabilizes inactive voltage gated Na channels
GABA receptor agoinst
