Bipolar Drugs Flashcards
3 classes of treatment
litium
anticonvulsants
atypical antipsychotics
first line bipolar
lithium
MOA lithium
not known
increases hippocampal and amygdala volume
therapeutic range Li
0.5-1.0
effects of >1.5 Li
tremor
nausea
diarrhea
effects of >2 Li
neurotoxicity
delirum
effects > 3 Li
fatal
Li clearance
renal
affected by diuretics and anti-inflammatory drugs
mild side effects Li
headache fatigue confusion thirst polyuria weakness
severe side effects Li
monoclonal jerks seizures impaired consciousness coma death
cardiac effects of Li
EKG irregularities
cardiac arrest
Li contraindications
pregnant
breastfeeding
effects of Li on fetus/baby
floppy baby syndrome
fetal goiter
Epstein’s abnormality
arrhythmias
second line bipolar drugs
anticonvulsants
carbamazepine
first gen anticonvulsant
stabilizes inactive voltage gated Na channels
GABA receptor agoinst
lamotrigine
second gen anticonvulsant
stabilizes inactive voltage gated Na channels
valproate
anticonvulsant
unknown MOA- enhances GABA function to decrease neuronal firing
atypical antipsychotics
positive and negative symptoms of schizophrenia
act on 5HT2a receptors
atypical antipsychotics for bipolar
aripiprazole ziprasidone resperidone asenapine quetiapine olanzapine
aripiprazole
atypical antipsychotic
ziprasidone
atypical antipsychotic
resperidone
atypical antipsychotic
asenapine
atypical antipsychotic
quetiapine
atypical antipsychotic
