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Block 6 > Antimalarial drugs > Flashcards

Antimalarial drugs Flashcards

1
Q

antimalaria symptoms

A 
malaise
myalgia
HA
fever- periodicity
rigor
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2
Q

ABCD of malaria prevention

A

aware of the risk
avoid bites
chemoprophylaxis
diagnose immediantly

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3
Q

blood smear for plasmodium falciparum

A

smaller ring
accole
maker’s spots
sickle shaped gametocytes

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4
Q

exposure for P falciparum

A

tropical

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5
Q

fever cycle for P falciparum

A

48h

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6
Q

most common cause of malaria

A

P falciparum

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7
Q

most chloroquine resistant

A

P falciparum

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8
Q

P falciparum is commonly resistant to

A

chloroquine
mefloquine
artemether

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9
Q

P vivax exposure

A

temperate

tropical

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10
Q

P vivax fever cycle

A

every 3rd day

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11
Q

relapsing

A

vivax
ovale
hypnozoites remain in liver

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12
Q

P vivax blood smear

A

in reticulocytes

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13
Q

P vivax and P ovale treatment

A

blood- anything

liver- primaquine

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14
Q

African blacks are resistant to

A

P vivax

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15
Q

P vivax is resistant to

A

chloroquine in indonesia and PNG

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16
Q

P ovale exposure

A

W africa

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17
Q

P ovale fever cycle

A

every 3rd day

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18
Q

P oval infects

A

reticulocytes

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19
Q

2 step treatment needed for

A

vivax

ovale

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20
Q

P malariae fever cycle

A

every 4th day

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21
Q

P malaria infects

A

old red blood cells

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22
Q

least common cause of malaria

A

P malaria

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23
Q

least virulent

A

P malariae

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24
Q

can infect on human primates

A

P lamariae

P knowlesi

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25
P knowlesi exposure
SE asia
26
P knowlesi fever cycle
daily
27
chloroquine phosphate resistance
Partial- India, western indonesia | signifant- SE Asia, PNG, Afriac
28
MOA chloroquine
inhibits heme polymerase and hemazoin formation which leads to toxic heme build up in the parasite and kills it
29
MOA chloroquine resistance
pumping out of the food vacule
30
side effects of chloroquine
GI upset itching psoriasis exacerbation bitter tastint
31
contraindications chloroquine
retinal disease | epilepsy
32
interactions chloroquine
intradermal rabies vaccine
33
chroloroquine prophylaxis
weekly central america hispaniola middle east
34
drugs safe in pregnancy
chloroquine mefloquine- prophylaxis quinine- treatment
35
mefloquine resistance area
SE Asia
36
mefloquine ADR
neuropsychiatric cardiac conduction seizures
37
mefloquine CI
``` seizures psychosis severe depression heart block fine motor requirement infants ```
38
mefloquine better for
prophylaxis
39
mefloquine prophylaxis schedule
weekly
40
doxycycline MOA
ribosome inhibition
41
doxycycline ADR
photosensitivity esophagitis yeast infections
42
doxycycline CI
kids
43
doxycycline interactions
``` seizure meds pepto-bismol iron antacids oral contraception ```
44
doxycycline prophylaxis
daily
45
chloroquine resistance treated with
doxycycline + quinine
46
atovaquone-proquanil ADR
GI upset HA mouth sores
47
atavaquone-proquanil CI
renal impairment | pregnancy
48
atovaquone-proquanil interactions
warfarin rifampin tetracycline
49
atovaquone-proquanil prophylaxis
dialy
50
#1 treatment of uncomplicated malira
atovaquone-proquanil
51
downside of atovaquone-proquanil
expensive
52
emergency self treatment
atovaquone-proquanil
53
primaquine phosphate resistance
africa
54
primaquine phosphate ADR
hemolysis in G6PD NV headache methemoglobinemia
55
primaquine phosphate CI
G6PD deficiency pregnancy Kids
56
primaquine phosphate prophylaxis
daily
57
terminal treatment for vivax and ovale
primaquine phosphate
58
when is primaquine phosphate prophylaxis used
only if nothing else works
59
OK for seizure patients
atovaquone-proquanil
60
quinine area of resistance
SE Asia
61
quinine MOA
inhibits hemozoin biocrystallization which allows heme to build up
62
quinine ADR
cinchonism bitter severe hypoglycemia
63
artemether-lumefantrin MOA
reduced by iron which causes reactive oxygen radicals to be released that damage the parasite
64
artmether-lumefantrin use
treatment
65
prophylaxis drugs
``` chloroquine mefloquine doxycycline atovaquone-proquanil primaquine ```

Block 6 (24 decks)

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