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Block 6 > Antimalarial drugs > Flashcards

Antimalarial drugs Flashcards

1
Q

antimalaria symptoms

A 
malaise
myalgia
HA
fever- periodicity
rigor
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2
Q

ABCD of malaria prevention

A

aware of the risk
avoid bites
chemoprophylaxis
diagnose immediantly

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3
Q

blood smear for plasmodium falciparum

A

smaller ring
accole
maker’s spots
sickle shaped gametocytes

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4
Q

exposure for P falciparum

A

tropical

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5
Q

fever cycle for P falciparum

A

48h

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6
Q

most common cause of malaria

A

P falciparum

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7
Q

most chloroquine resistant

A

P falciparum

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8
Q

P falciparum is commonly resistant to

A

chloroquine
mefloquine
artemether

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9
Q

P vivax exposure

A

temperate

tropical

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10
Q

P vivax fever cycle

A

every 3rd day

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11
Q

relapsing

A

vivax
ovale
hypnozoites remain in liver

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12
Q

P vivax blood smear

A

in reticulocytes

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13
Q

P vivax and P ovale treatment

A

blood- anything

liver- primaquine

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14
Q

African blacks are resistant to

A

P vivax

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15
Q

P vivax is resistant to

A

chloroquine in indonesia and PNG

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16
Q

P ovale exposure

A

W africa

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17
Q

P ovale fever cycle

A

every 3rd day

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18
Q

P oval infects

A

reticulocytes

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19
Q

2 step treatment needed for

A

vivax

ovale

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20
Q

P malariae fever cycle

A

every 4th day

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21
Q

P malaria infects

A

old red blood cells

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22
Q

least common cause of malaria

A

P malaria

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23
Q

least virulent

A

P malariae

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24
Q

can infect on human primates

A

P lamariae

P knowlesi

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25
Q

P knowlesi exposure

A

SE asia

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26
Q

P knowlesi fever cycle

A

daily

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27
Q

chloroquine phosphate resistance

A

Partial- India, western indonesia

signifant- SE Asia, PNG, Afriac

28
Q

MOA chloroquine

A

inhibits heme polymerase and hemazoin formation which leads to toxic heme build up in the parasite and kills it

29
Q

MOA chloroquine resistance

A

pumping out of the food vacule

30
Q

side effects of chloroquine

A

GI upset
itching
psoriasis exacerbation
bitter tastint

31
Q

contraindications chloroquine

A

retinal disease

epilepsy

32
Q

interactions chloroquine

A

intradermal rabies vaccine

33
Q

chroloroquine prophylaxis

A

weekly
central america
hispaniola
middle east

34
Q

drugs safe in pregnancy

A

chloroquine
mefloquine- prophylaxis
quinine- treatment

35
Q

mefloquine resistance area

A

SE Asia

36
Q

mefloquine ADR

A

neuropsychiatric
cardiac conduction
seizures

37
Q

mefloquine CI

A 
seizures
psychosis
severe depression
heart block
fine motor requirement
infants
38
Q

mefloquine better for

A

prophylaxis

39
Q

mefloquine prophylaxis schedule

A

weekly

40
Q

doxycycline MOA

A

ribosome inhibition

41
Q

doxycycline ADR

A

photosensitivity
esophagitis
yeast infections

42
Q

doxycycline CI

A

kids

43
Q

doxycycline interactions

A 
seizure meds
pepto-bismol
iron
antacids
oral contraception
44
Q

doxycycline prophylaxis

A

daily

45
Q

chloroquine resistance treated with

A

doxycycline + quinine

46
Q

atovaquone-proquanil ADR

A

GI upset
HA
mouth sores

47
Q

atavaquone-proquanil CI

A

renal impairment

pregnancy

48
Q

atovaquone-proquanil interactions

A

warfarin
rifampin
tetracycline

49
Q

atovaquone-proquanil prophylaxis

A

dialy

50
Q

1 treatment of uncomplicated malira

A

atovaquone-proquanil

51
Q

downside of atovaquone-proquanil

A

expensive

52
Q

emergency self treatment

A

atovaquone-proquanil

53
Q

primaquine phosphate resistance

A

africa

54
Q

primaquine phosphate ADR

A

hemolysis in G6PD
NV
headache
methemoglobinemia

55
Q

primaquine phosphate CI

A

G6PD deficiency
pregnancy
Kids

56
Q

primaquine phosphate prophylaxis

A

daily

57
Q

terminal treatment for vivax and ovale

A

primaquine phosphate

58
Q

when is primaquine phosphate prophylaxis used

A

only if nothing else works

59
Q

OK for seizure patients

A

atovaquone-proquanil

60
Q

quinine area of resistance

A

SE Asia

61
Q

quinine MOA

A

inhibits hemozoin biocrystallization which allows heme to build up

62
Q

quinine ADR

A

cinchonism
bitter
severe hypoglycemia

63
Q

artemether-lumefantrin MOA

A

reduced by iron which causes reactive oxygen radicals to be released that damage the parasite

64
Q

artmether-lumefantrin use

A

treatment

65
Q

prophylaxis drugs

A 
chloroquine
mefloquine
doxycycline
atovaquone-proquanil
primaquine

Block 6 (24 decks)

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