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Block 6 > Myeloproliferative Neoplasms > Flashcards

Myeloproliferative Neoplasms Flashcards

1
Q

acute myeloid leukemia

A

myelodysplastic syndromes

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2
Q

acute myeloid leukemia

A

myelodysplastic syndromes

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3
Q

acute lymphoid leukemia

A

lymphoma

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4
Q

chronic myeloid leukemia

A

myeloproliferative neoplasms

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5
Q

chronic lymphoid leukemia

A

lymphoma

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6
Q

characteristics of acute

A

kids

cells can’t mature

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7
Q

characteristics of chronic

A

adults

cells can’t die

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8
Q

age for myeloproliferative neoplasms

A

40-60y

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9
Q

marrow cellularity

A

increased

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10
Q

barrow blasts

A

normal to increased

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11
Q

mature or immature cells

A

mature

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12
Q

morphology

A

normal

abnormal megakaryocytes

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13
Q

hematopoesis

A

effectiveness

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14
Q

cell lines increased

A

1 or more
RBC
granulocytes
megakaryocytes

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15
Q

organ enlargment

A

common
liver
spleen

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16
Q

signaling pathway involved

A

tyrosine kinase

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17
Q

chronic pahse

A
18
Q

acute blast phase

A

> 20% blasts

marrow failure

19
Q

acute blast phase

A

> 20% blasts

marrow failure

20
Q

polycythemia vera

A 
increased proliferation of erythroid precursors
JAK2 mutation
male
issues due to high viscosity blood
poikilocytosis
treatment- phelobotmy
decreased EPO
increased RBC mass in proliferative phase only
spent phase- normal/decreased RBC mass
21
Q

chronic myeloid leukemia

A

myeloproliferative neoplasms

22
Q

chronic lymphoid leukemia

A

lymphoma

23
Q

characteristics of acute

A

kids

cells can’t mature

24
Q

characteristics of chronic

A

adults

cells can’t die

25
Q

age for myeloproliferative neoplasms

A

40-60y

26
Q

marrow cellularity

A

increased

27
Q

barrow blasts

A

normal to increased

28
Q

mature or immature cells

A

mature

29
Q

morphology

A

normal

abnormal megakaryocytes

30
Q

hematopoesis

A

effectiveness

31
Q

cell lines increased

A

1 or more
RBC
granulocytes
megakaryocytes

32
Q

organ enlargment

A

common
liver
spleen

33
Q

signaling pathway involved

A

tyrosine kinase

34
Q

chronic pahse

A
35
Q

accelerated phase

A

10-19% blasts

36
Q

acute blast phase

A

> 20% blasts

marrow failure

37
Q

chronic myelogenous leukemia

A

increased proliferation of granulocytes, specifically basophils
9,22 translocation- BCR/ABL fusion protein (philadelphia chromosome)
splenomegaly
treatment- imatinab
LAP negative

38
Q

polycythemia vera

A 
increased proliferation of erythroid precursors
JAK2 mutation
male
issues due to high viscosity blood
treatment- phelobotmy
decreased EPO
increased RBC mass in proliferative phase only
spent phase- normal/decreased RBC mass
39
Q

essential thrombocytopenia

A 
increased platelets
JAK2 mutation
30y female
avoid splenectomy
doesn't progress to marrow fibrosis or acute leukemia
40
Q

primary myelofibrosis

A 
increased megakaryocytic
JAK2 mutation
splenomegaly- extra medullary hematopoiesis
poikilocytosis
marrow fibrosis
leukoerythroblastic smear

Block 6 (24 decks)

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