Myeloproliferative Neoplasms

Question 1

acute myeloid leukemia

Answer 1

myelodysplastic syndromes

Question 2

acute myeloid leukemia

Answer 2

myelodysplastic syndromes

Question 3

acute lymphoid leukemia

Answer 3

lymphoma

Question 4

chronic myeloid leukemia

Answer 4

myeloproliferative neoplasms

Question 5

chronic lymphoid leukemia

Answer 5

lymphoma

Question 6

characteristics of acute

Answer 6

kids

cells can’t mature

Question 7

characteristics of chronic

Answer 7

adults

cells can’t die

Question 8

age for myeloproliferative neoplasms

Answer 8

40-60y

Question 9

marrow cellularity

Answer 9

increased

Question 10

barrow blasts

Answer 10

normal to increased

Question 11

mature or immature cells

Answer 11

mature

Question 12

morphology

Answer 12

normal

abnormal megakaryocytes

Question 13

hematopoesis

Answer 13

effectiveness

Question 14

cell lines increased

Answer 14

1 or more
RBC
granulocytes
megakaryocytes

Question 15

organ enlargment

Answer 15

common
liver
spleen

Question 16

signaling pathway involved

Answer 16

tyrosine kinase

Question 17

chronic pahse

Question 18

acute blast phase

Answer 18

> 20% blasts

marrow failure

Question 19

acute blast phase

Answer 19

> 20% blasts

marrow failure

Question 20

polycythemia vera

Answer 20

increased proliferation of erythroid precursors
JAK2 mutation
male
issues due to high viscosity blood
poikilocytosis
treatment- phelobotmy
decreased EPO
increased RBC mass in proliferative phase only
spent phase- normal/decreased RBC mass

Question 21

chronic myeloid leukemia

Answer 21

myeloproliferative neoplasms

Question 22

chronic lymphoid leukemia

Answer 22

lymphoma

Question 23

characteristics of acute

Answer 23

kids

cells can’t mature

Question 24

characteristics of chronic

Answer 24

adults

cells can’t die

Question 25

age for myeloproliferative neoplasms

Answer 25

40-60y

Question 26

marrow cellularity

Answer 26

increased

Question 27

barrow blasts

Answer 27

normal to increased

Question 28

mature or immature cells

Answer 28

mature

Question 29

morphology

Answer 29

normal

abnormal megakaryocytes

Question 30

hematopoesis

Answer 30

effectiveness

Question 31

cell lines increased

Answer 31

1 or more
RBC
granulocytes
megakaryocytes

Question 32

organ enlargment

Answer 32

common
liver
spleen

Question 33

signaling pathway involved

Answer 33

tyrosine kinase

Question 34

chronic pahse

Question 35

accelerated phase

Answer 35

10-19% blasts

Question 36

acute blast phase

Answer 36

> 20% blasts

marrow failure

Question 37

chronic myelogenous leukemia

Answer 37

increased proliferation of granulocytes, specifically basophils
9,22 translocation- BCR/ABL fusion protein (philadelphia chromosome)
splenomegaly
treatment- imatinab
LAP negative

Question 38

polycythemia vera

Answer 38

increased proliferation of erythroid precursors
JAK2 mutation
male
issues due to high viscosity blood
treatment- phelobotmy
decreased EPO
increased RBC mass in proliferative phase only
spent phase- normal/decreased RBC mass

Question 39

essential thrombocytopenia

Answer 39

increased platelets
JAK2 mutation
30y female
avoid splenectomy
doesn't progress to marrow fibrosis or acute leukemia

Question 40

primary myelofibrosis

Answer 40

increased megakaryocytic
JAK2 mutation
splenomegaly- extra medullary hematopoiesis
poikilocytosis
marrow fibrosis
leukoerythroblastic smear