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Block 6 > Mature B Cell Lymphomas > Flashcards

Mature B Cell Lymphomas Flashcards

1
Q

Mature B cell lymphoma clinical outcome determined by

A

stage of differentiation

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2
Q

t(11,14)

A

mantle cell lymphoma

cyclin D1

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3
Q

t(14,18)

A

follicular cell lymphoma

BCL2

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4
Q

t(8,14)

A

Burkitt lymhpoma

proliferation

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5
Q

who gets mature B cell lymphomas

A

50-60y

kids

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6
Q

EBV association

A

burkitt lymphoma

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7
Q

hepatitis C association

A

lymphoblastic lymphoma

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8
Q

indolent disease survival

A

> 5y

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9
Q

slowly aggressive survival

A

3y

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10
Q

aggressive disease survival

A

curable

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11
Q

most common mature B cell lymhpomas

A

large B cell lymphoma

follicular lymhpoma

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12
Q

chronic lymphocytic leukemia

A

lymphocyte expansion in blood
basket cells
are healthy on presentation

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13
Q

small lymphocytic lymphoma

A

lymph involvement

present with enlarged nodes

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14
Q

CD19, 20, 22

A

B cell

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15
Q

CD5

A

mantle origin

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16
Q

CLL/SLL no somatic mutation prognosis

A

bad

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17
Q

CLL/SLL somatic mutation prognosis

A

good

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18
Q

CLL/SLL prognosis

A

7y

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19
Q

Richter syndrome

A

transformation of SLL/CLL into large cell lymhphoma

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20
Q

men >50y
healthy OR lymph node enlargement
CD5+
CD19, CD20, CD22 +

A

CLL/SLL

21
Q 
60y M
lymph, blood, extra nodal
CD19, CD20, CD22
cyclin D1
t(11,14)
CD5+
A

MCL

22
Q

lymphomatous polyposis assocaition

A

MCL

23
Q

mature b cell lymphoma associated with females

A

follicular lymphoma

24
Q 
55F, young men
CD19, 20, 22 +
CD10, BCL6 +
centrocytes/centroblasts
paratragecular aggregates
BCL2 +
t(14,18)
A

follicular lymphoma

25
Q

most common large cell lymphoma transformation

A

follicular lymphoma

26
Q

types that can transform to large cell lymhpoma

A

follicular lymphoma

CLL/SLL

27
Q

rapidly enlarging masses- GI, ovary, lung
secondary or primary (EBV, immunocompromised)
CD19, 20, 22 +
germinal center OR activated blood B-cell types
CD10 +-

A

diffuse large B cell lymphoma

28
Q

rituximab

A

anti CD20

29
Q

most agressive mature B cell lymphoma

A

burkitt lymphoma

30
Q

facial bone involvement

A

endemic burkitt lymphoma

31
Q

abdominal mass involvement

A

sporadic burkitt lymphoma

32
Q

young kid from africa with large mass on face that grows very fast

A

burkitt lymphoma

33
Q

prepubescent girl with breast development

A

burkitt lymphoma

34
Q

starry sky appearance

A

Burkett lymphoma

35
Q 
CD10 BCL6 +
CD19, CD20, CD22 +
TdT neg 
KI67 index 100%
t(8,14)
A

Burkitt lymphoma

36
Q

burkitt lymphoma prognosis

A

90% survival if caught early

need 2y disease free to be considered cured

37
Q

burkitt lymphoma treatment

A

short term chemo- always dividing cells

38
Q 
50y M
hairy cells
lymphocytes secreting monocyte inhibitors
splenomegaly
fried egg appearance of bone marrow with dry tap
red pulp involvement
103, 25, 11c +
cyclin D +
TRAP +
A

hairy cell leukemia

39
Q

disease of memory B cells

A

hairy cell leukemia

40
Q

treatment hairy cell leukemia

A

purine nucleoside analog (deoxycoformycin)

41
Q 
63y M
Waldenstrom macroglobulinemia
hyper viscosity
hepatitis C
Rouleaux
CD19, 20, 22
IgM
A

lymphoplasmacytic lymphoma

42
Q

Waldenstrom macroglobulinemia

A

bone marrow involvement with IgM spike in blood

43
Q 
70y M black
hypercalcemia
renal insufficiency
anemia
lytic bone lesions
spike M component- IgG, IgA, IgD in serum or urine
Mott cell
with symptoms
lytic lesions in flat bones
A

plasma cell myeloma

44
Q 
70y M black
hypercalcemia
renal insufficiency
anemia
lytic bone lesions
spike M component- IgM (+/-)
Mott cell
without symptoms
A

monoclonal gammopathy of undetermined significance

45
Q

order a serum and urine test if you suspect

A

plasma cell myeloma

46
Q

plasma cell myeloma prognosis with kidney damage

A
47
Q

plasma cell myeloma with limited symptoms prognosis

A

several years

48
Q

CRAB

A 
hyperCalcinemia
renal insufficiency
anemia
lytic Bone lesions
associated with plasma cell myeloma

Block 6 (24 decks)

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